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Addex Therapeutics (ADXN) investor relations material
Addex Therapeutics Q3 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q3 2025 earnings summary4 Dec, 2025
Executive summary
Advanced GABAB PAM program for chronic cough, with preclinical characterization completed and a backup compound selected; Indivior selected a GABAB PAM for substance use disorder.
Dipraglurant repositioned for brain injury recovery, with preclinical profiling ongoing and clinical study preparations underway.
Neurosterix spin-out progressing with M4 PAM schizophrenia program and IND-enabling studies completed; divestment of allosteric modulator platform to Neurosterix in April 2024, receiving CHF 5.0 million and a 20% equity stake.
Investment in Stalicla, which is advancing patient stratification studies in autism and exploring broader applications.
Lead compound ADX71149 returned from Janssen after failed Phase 2 study.
Financial highlights
Q3 2025 income was CHF 0.1 million, mainly from Indivior patent license and Neurosterix services; revenue for the nine months ended September 30, 2025 was CHF 30k, down from CHF 402k year-over-year.
Net loss for the nine months ended September 30, 2025 was CHF 4.9 million, compared to a net profit of CHF 8.3 million in 2024.
Cash and cash equivalents at September 30, 2025 were CHF 2.2 million, down from CHF 3.3 million at year-end 2024.
Operating costs for the nine months ended September 30, 2025 decreased to CHF 2.2 million from CHF 2.7 million year-over-year.
Recognized CHF 0.9 million share of Neurosterix net loss in Q3, and CHF 3.0 million for the nine months ended September 30, 2025.
Outlook and guidance
Existing cash is expected to fund operations through mid-June 2026, but does not fund unpartnered programs into the clinic; additional financing required.
IND-enabling studies for GABAB PAM chronic cough program ready to start pending financing.
Neurosterix M4 PAM program on track to dose patients this year.
Stalicla pursuing Series C financing and considering IPO as markets improve.
Expenses are expected to increase as clinical and preclinical programs advance.
Funding plan for GABAB PAM IND studies
GABAB PAM differentiation vs. P2X3 inhibitors
Stalicla's next funding catalyst or IPO plans
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Next Addex Therapeutics earnings date
H2 20256 Apr, 2026
Next Addex Therapeutics earnings date
H2 20256 Apr, 2026
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Frequently asked questions
Addex Therapeutics Ltd is a biotechnology company focused on the discovery and development of small molecule therapies for neurological disorders. The company specializes in allosteric modulators, a drug discovery approach aimed at targeting specific receptors in the central nervous system to treat conditions such as Parkinson’s disease, epilepsy, and schizophrenia. Addex conducts clinical and preclinical research to advance its pipeline of investigational treatments. The company is headquartered in Geneva, Switzerland, and its shares are listed on the SIX Swiss Exchange.
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