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Affimed (AFMD) investor relations material
Affimed Leerink’s Global Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Leerink’s Global Healthcare Conference 2025 summary11 Mar, 2025
Executive leadership and strategic focus
New CEO with extensive biotech experience, including successful fundraising and public offerings.
Pipeline prioritization is driven by investor input and commercial potential of assets.
AFM24 and AFM28 are the main focus due to strong data and significant unmet needs.
Acimtamig may be deprioritized due to lower commercial potential.
Investor and partner interests are aligned, focusing on late-phase and high-potential programs.
Clinical program updates and data
AFM24 shows promising response rates and PFS in both EGFR wild type and mutant NSCLC, especially in combination with checkpoint inhibitors.
Higher AFM24 doses are being pursued based on post-hoc analysis showing dose-response correlation.
AFM28 in AML demonstrates a 40% composite CR rate at 300 mg, with responses up to 6.5 months.
Next steps for AFM28 include dose escalation to level seven, with data expected in 6–9 months after enrollment.
Acimtamig, in combination with Artiva’s NK cells, maintains high response rates, with durability data pending.
Business development and partnering
Partnering discussions for Acimtamig are complicated by economic splits and market size.
Expanding Acimtamig into PTCL could triple its commercial opportunity.
Commercial viability and global access are key considerations in NK cell sourcing and regimen design.
AFM24’s synergy with multiple checkpoint inhibitors supports flexibility in future development.
Ongoing investor and partner feedback shapes program prioritization and trial design.
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Frequently asked questions
Affimed N.V., a clinical-stage biopharmaceutical company, focuses on discovering and developing cancer immunotherapies in the United States, Europe, and Germany. The company operates through two segments, Affimed Therapeutics, and Redoxa GmbH. It develops therapies based on its proprietary TandAb platform to unleash the innate power of the immune system by harnessing the functionality of natural killer cells and T-cells for the treatment of cancer.
The company has strategic partnerships with Genentech Inc.; Merck KGaA and Pfizer Inc.; Novartis Institutes for BioMedical Research, Inc.; Celgene Corporation; Bayer Pharma AG; MorphoSys AG; Incyte Corporation; Amgen Inc.; Hoffmann-La Roche ltd; Sanofi S.A.; and Bristol-Myers Squibb Company. Affimed N.V. was founded in 2000 and is headquartered in Heidelberg, Germany
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