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Agenus (AGEN) investor relations material
Agenus H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Key scientific and clinical insights
Botensilimab is a next-generation Fc-enhanced CTLA-4 inhibitor with mutations that improve immune activation and reduce immunosuppression compared to first-generation agents.
The drug shows efficacy in cold tumors, such as MSS colorectal and pancreatic cancers, by increasing immune infiltration and depleting T-regs.
An additional mutation reduces complement binding, leading to lower rates of immune-mediated adverse events like hypophysitis.
Clinical development and trial updates
There are 35 active investigator-initiated studies across a wide range of tumor types and disease stages.
In refractory MSS colorectal cancer, median overall survival is around 20 months, with a 20% response rate and 24-month survival exceeding 40%.
The Batman phase 3 trial will enroll 834 patients, comparing BOT-BELL to best supportive care, with FDA agreement on design and endpoints.
The trial includes both liver and non-liver metastasis patients, with analyses planned for both subgroups.
Market opportunity and commercialization plans
The fourth-line MSS colorectal cancer market in the U.S. is about 10,000 patients, representing a significant opportunity.
Commercialization discussions are ongoing, with potential for global or regional partnerships, but internal launch capability is also established.
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