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AIM ImmunoTech (AIM) investor relations material

AIM ImmunoTech has been delisted

AIM ImmunoTech Virtual Investor Closing Bell Series summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Virtual Investor Closing Bell Series summary4 Dec, 2025

Lead asset overview

  • Ampligen is positioned as a platform drug in immuno-oncology, showing potential as both a monotherapy and a synergistic enhancer to checkpoint inhibitors across various solid tumors.

  • Data indicates Ampligen improves response rates in patients refractory to checkpoint blockade therapy, addressing a significant unmet need.

Strategic focus and rationale

  • The company has shifted its primary focus to immuno-oncology, with a strategic decision to prioritize pancreatic cancer as the lead indication.

  • Pancreatic cancer was chosen due to its high unmet medical need, significant market opportunity, and the potential for Ampligen to extend overall survival.

  • Orphan drug designations and a strong patent estate provide market exclusivity in the US and EU for Ampligen in pancreatic cancer.

Clinical and regulatory strategy

  • Ongoing Phase II trial in metastatic pancreatic cancer in collaboration with AstraZeneca and its drug durvalumab (Imfinzi) is showing promising synergistic results.

  • The company is committed to providing mid-year and year-end data updates, with the next major milestone being the year-end clinical report.

  • Plans are underway to initiate a Phase III trial, seeking a big pharma partner to support late-stage development and commercialization.

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Frequently asked questions

AIM ImmunoTech Inc., formerly known as Hemispherx Biopharma, Inc., is an immuno-pharmaceutical company dedicated to the research and development of therapeutics for the treatment of multiple types of cancers, viral diseases, and immune-deficiency disorders. The company's leading product candidate is Ampligen, a drug composed of macromolecular ribonucleic acid molecules aimed at treating chronic fatigue syndrome (CFS). Ampligen is also under development for various cancer types, including renal cell carcinoma, malignant melanoma, and others, as well as for conditions like Hepatitis B, HIV, COVID-19, and post-COVID conditions. Another key product is Alferon N Injection, an injectable formulation of natural alpha interferon for treating human papillomavirus (HPV) and genital warts. The company is headquartered in Ocala, Florida, and its shares are listed on the NYSE.

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