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Akari Therapeutics (AKTX) investor relations material

Akari Therapeutics Q2 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q2 2025 earnings summary13 Aug, 2025

Executive summary

  • Focus shifted to next-generation antibody-drug conjugates (ADCs) after the Peak Bio merger, with legacy programs suspended or seeking external partners.

  • Lead candidate AKTX-101 targets Trop2 in solid tumors, leveraging a novel PH1 payload for improved efficacy and immune activation.

  • Significant operational restructuring in May 2024, including a 67% workforce reduction and management changes, to align with new R&D priorities.

  • No commercial products or product revenue to date; ongoing reliance on external financing.

Financial highlights

  • Net loss for Q2 2025 was $1.9 million, a 75% improvement year-over-year; six-month net loss was $5.6 million, down 57% from prior year.

  • Operating expenses for Q2 2025 decreased 58% to $3.1 million, driven by lower R&D and absence of merger/restructuring costs.

  • Cash and restricted cash at June 30, 2025 totaled $2.7 million; accumulated deficit reached $252.9 million.

  • Recognized a $1.2 million gain on settlement of current liabilities in Q2 2025.

  • No revenue generated; all expenses relate to R&D and G&A.

Outlook and guidance

  • Cash and committed funds expected to fund operations into October 2025; additional capital will be required to continue beyond that point.

  • Management is actively pursuing further financing, including equity, debt, and strategic partnerships.

  • Substantial doubt exists regarding ability to continue as a going concern without new funding.

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Frequently asked questions

Akari Therapeutics PLC is a clinical-stage biopharmaceutical company focused on developing treatments for autoimmune and inflammatory diseases. The company’s research primarily targets conditions involving the complement and leukotriene pathways, which play key roles in immune system regulation. Akari Therapeutics is headquartered in London, United Kingdom, and its shares are listed on the NASDAQ.

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