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Akebia Therapeutics (AKBA) investor relations material
Akebia Therapeutics H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary8 Sep, 2025
Commercial performance and product focus
Vafseo generated over $13 million in Q2 revenue with 55% demand growth, driven by both breadth and depth of prescribing, including 725 prescribers and strong penetration in US Renal Care clinics.
Auryxia, despite loss of IP exclusivity, achieved 15% year-over-year growth and continues to contribute to revenue, supported by favorable economics and clinical profile.
Vafseo's dosing in real-world use aligns with clinical trial data, with 80% of Q2 prescriptions being refills and average doses increasing over time.
Expansion into dialysis organizations and market opportunity
Innovative Renal Care and Dialysis Clinic Inc. have operationalized protocols, providing access to 32,000 patients, with DaVita's pilot potentially opening access to 204,000 patients by year-end.
The total addressable market includes 550,000 anemic CKD patients on dialysis, with ongoing efforts to engage Fresenius for future access, targeting P&T committee review in 2026.
Clinical development and future growth drivers
The VACE trial aims to demonstrate reductions in hospitalization and mortality, supporting Vafseo's case as a standard of care and offering significant economic benefits to dialysis organizations.
The Phase 3 VALOR trial for non-dialysis CKD patients is planned to start by year-end, targeting a similarly sized patient population and representing a multi-billion dollar opportunity.
Broad usage of Vafseo has been observed, not limited to home or high-dose ESA patients, indicating strong market acceptance.
DaVita pilot progress and full access timeline
NDD market: What makes it a multi-billion opportunity?
Auryxia's Q2 growth: How sustainable is this?
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Next Akebia Therapeutics earnings date
Q3 20256 Nov, 2025
Next Akebia Therapeutics earnings date
Q3 20256 Nov, 2025
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Frequently asked questions
Akebia Therapeutics, Inc., a biopharmaceutical company, focuses on the development and commercialization of therapeutics for patients with kidney diseases. The company's lead product candidate include Vadadustat, an oral therapy for the treatment of anemia due to chronic kidney disease in non-dialysis and dialysis patients; and AKB-9778, which is intended for the treatment of hypoxia-inducible factor stabilization. Its clinical programs also comprise AKB-6548, for the treatment of asthma, chronic obstructive pulmonary disease, and idiopathic pulmonary fibrosis; AKB-5169 for the treatment of pain associated with osteoarthritis; and AKB-6899 for use as a bioavailable prodrug of oxaloacetate to treat disorders accompanied by oxidative stress.
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