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Edge12 Dec 2025
Running on Clouds: The Story of On
The story of how a Swiss runner's pursuit of a new running sensation became On, aiming to be the most premium global sportswear brand worldwide.
Aktis Oncology
Aktis Oncology (AKTS) investor relations material
Aktis Oncology Registration Filing summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Registration Filing summary7 Jan, 2026
Company overview and business model
Clinical-stage oncology company developing targeted radiopharmaceuticals for solid tumors using a proprietary miniprotein radioconjugate platform.
Lead program targets Nectin-4, with additional pipeline targeting B7-H3 and other clinically validated tumor antigens.
Platform designed for high tumor penetration, selectivity, and rapid clearance to minimize toxicity.
Strategic collaboration with Eli Lilly for novel radiopharmaceuticals, retaining rights to core pipeline.
Building integrated supply chain and cGMP manufacturing to support clinical and future commercial needs.
Financial performance and metrics
No product revenue to date; revenue derived from Eli Lilly collaboration ($60M upfront, $1M milestone in 2025).
Net loss of $48.6M for the nine months ended September 30, 2025; $44.0M net loss for 2024.
Accumulated deficit of $141.4M as of September 30, 2025.
Cash, cash equivalents, and marketable securities of $246.2M as of September 30, 2025.
Research and development expenses were $51.0M for the nine months ended September 30, 2025.
Use of proceeds and capital allocation
Estimated net proceeds of $274.5M from IPO (at $17/share midpoint), or $316.4M if underwriters' option exercised.
Proceeds to fund Phase 1b trial of lead candidate, advance B7-H3 program, and for working capital and public company costs.
Funds expected to support operations into 2029, but not through regulatory approval of any product candidate.
AKY-1189 patient selection strategy?
Ensure 225Ac supply chain reliability?
Eli Lilly collaboration's strategic impact?
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Aktis Oncology
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