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Aktis Oncology (AKTS) investor relations material
Aktis Oncology Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
FDA cleared IND applications for AKY-2519, enabling a Phase 1b clinical trial in mid-2026 targeting B7-H3 in solid tumors.
Lead program AKY-1189, targeting Nectin-4, is enrolling in a Phase 1b trial and received FDA Fast Track designation in February 2026.
IPO in January 2026 raised $365.4M gross, supporting expansion and clinical development.
Financial highlights
Cash, cash equivalents, and marketable securities were $226.8M as of December 31, 2025; pro forma as adjusted cash post-IPO is $562.1M.
Collaboration revenue rose to $6.5M for 2025 from $1.5M in 2024, mainly from the Eli Lilly partnership.
R&D expenses increased to $67.5M in 2025 from $41.0M in 2024, driven by higher headcount and program advancement.
G&A expenses were $13.7M in 2025, up from $12.6M in 2024, reflecting business growth.
Net loss widened to $63.7M in 2025 from $44.0M in 2024, primarily due to increased R&D spending.
Outlook and guidance
Preliminary data from Part 1 of the AKY-1189 Phase 1b trial expected in Q1 2027.
Results from AKY-2519 imaging and dosimetry assessment expected mid-2026; Phase 1b trial to start mid-2026.
Early pipeline programs aim for development candidate nomination and IND-enabling activities in Q1 2027.
In-house GMP facility expected operational in H2 2026 to support clinical supply.
Pro forma cash position expected to fund operations into 2029.
- Innovative radiopharmaceutical platform advances with strong pipeline, partnerships, and cash runway.AKTS
Leerink Global Healthcare Conference 20269 Mar 2026 - First-in-class radiopharmaceuticals advance toward major milestones in a growing market.AKTS
TD Cowen 46th Annual Health Care Conference3 Mar 2026 - IPO seeks $274.5M to fund radiopharmaceutical cancer pipeline, with Eli Lilly as key partner.AKTS
Registration Filing7 Jan 2026 - IPO seeks $181.7M to advance radiopharmaceutical pipeline, with Eli Lilly partnership and strong cash.AKTS
Registration Filing5 Jan 2026 - Developing next-gen radiopharmaceuticals for solid tumors, leveraging strong cash and Eli Lilly partnership.AKTS
Registration Filing29 Dec 2025
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Next Aktis Oncology earnings date
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