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Aligos Therapeutics (ALGS) investor relations material
Aligos Therapeutics Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary17 Nov, 2025
Portfolio overview and pipeline updates
Lead program pevifoscorvir (pevi) targets hepatitis B, with a robust phase II pipeline including a beta thyroid agonist (ALG-009) and a pan-coronavirus protease inhibitor in phase II in the UK.
Preclinical assets include antisense oligonucleotides for hepatitis B and delta viruses, and obesity research.
Hepatitis B disease landscape and unmet need
Chronic HBV affects 250 million globally, leading to liver disease and cancer; current therapies (nucleoside analogs, pegylated interferon) have limited efficacy and safety.
Achieving full viral suppression (<12 IU HBV DNA) significantly reduces risk of liver cancer, but many patients do not reach this with standard care.
Mechanism and clinical data for pevifoscorvir
Pevi, a capsid assembly modulator, blocks both viral replication and cccDNA establishment, addressing key drivers of HBV progression.
Modified for improved bioavailability, pevi showed full HBV DNA suppression and antigen reduction in early clinical studies.
In phase II, pevi outperformed tenofovir in HBV DNA reduction, with 100% of E negative and 60% of E positive patients below detection at 48 weeks, and no drug resistance observed.
Antigen reductions and sustained off-treatment responses indicate cccDNA suppression; safety profile is favorable with only transient ALT elevations.
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Next Aligos Therapeutics earnings date
Piper Sandler 37th Annual Healthcare Conference3 Dec, 2025
Next Aligos Therapeutics earnings date
Piper Sandler 37th Annual Healthcare Conference3 Dec, 2025
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Frequently asked questions
Aligos Therapeutics Inc. is a clinical-stage biopharmaceutical company engaged in the development of novel therapeutics to address unmet medical needs in viral and liver diseases. The company's development pipeline includes drug candidates for the treatment of conditions such as non-alcoholic steatohepatitis (NASH), chronic hepatitis B (CHB), and coronavirus. Aligos Therapeutics utilizes a combination of small molecule and oligonucleotide platforms to create pharmacologically optimized drug candidates aimed at improving treatment outcomes in these diseases. The company is headquartered in South San Francisco, California, and its shares are listed on the Nasdaq.
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