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Allogene Therapeutics (ALLO) investor relations material
Allogene Therapeutics Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary18 Nov, 2025
Corporate and program overview
Three clinical programs in development: Cema-Cel (lead, CD19-directed), ALLO-329 (dual CD19/CD70), and ALLO-316 (solid tumor, renal cell cancer).
Manufacturing scaled to 60,000 doses/year with biologics-level cost efficiency.
Infrastructure supports both clinical pipeline and future commercialization.
Cema-Cel program and ALPHA3 study
Cema-Cel targets MRD-positive non-Hodgkin's lymphoma patients post R-CHOP, focusing on frontline consolidation.
Study randomizes 220 MRD-positive patients to Cema-Cel or observation; primary endpoint is event-free survival.
Interim biomarker analysis (MRD conversion) expected first half of 2026; clinical endpoints to follow.
Over 50 sites active, split between academic and community centers, aiming to expand CAR T access.
Market opportunity for frontline consolidation estimated at $5B in US/EU, significantly larger than current settings.
ALLO-329 and ALLO-316 programs
ALLO-329 explores autoimmune indications with dual CAR, aiming for low/no lymphodepletion; initial data expected H1 2026.
Resolution study tests cyclophosphamide-only and no lymphodepletion arms, leveraging CD70 technology for cell expansion.
ALLO-316 in renal cell cancer shows 31% response rate and durable responses beyond one year from a single infusion.
Safety profile for ALLO-316 consistent with active CAR T therapies, with measures in place for adverse events.
What MRD conversion rate signals AlphaTreE success?
What data confirms Allo329's low lymphodepletion?
How does Allo316 durability compare to hematologic?
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Next Allogene Therapeutics earnings date
Piper Sandler 37th Annual Healthcare Conference2 Dec, 2025
Next Allogene Therapeutics earnings date
Piper Sandler 37th Annual Healthcare Conference2 Dec, 2025
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Frequently asked questions
Allogene Therapeutics Inc is a biotechnology company focused on developing allogeneic CAR T cell therapies for cancer treatment. The company’s approach uses gene-editing and cell engineering technologies to produce off-the-shelf immunotherapies designed to target various hematologic and solid tumors. Its operations span research, clinical trials, and manufacturing. Allogene Therapeutics Inc is headquartered in South San Francisco, California, and its shares are listed on the NASDAQ.
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