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Allogene Therapeutics (ALLO) investor relations material
Allogene Therapeutics Piper Sandler 37th Annual Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Piper Sandler 37th Annual Healthcare Conference summary2 Dec, 2025
Strategic focus and clinical program updates
Allogeneic cell therapy aims to democratize treatment by reducing costs and expanding access to community cancer centers.
Lead CD19-directed CAR-T program, Cema-cel, is being evaluated in the Alpha3 study for large B-cell lymphoma as a consolidation therapy post-R-CHOP.
Alpha3 study uses MRD testing post-R-CHOP to identify high-risk patients for randomization to Cema-cel or observation.
Interim analysis of Alpha3, focusing on MRD conversion rates, is expected in the first half of next year; primary event-free survival data will follow.
Approximately half of trial sites are community-based, with most patients treated in outpatient settings.
Clinical trial design and expectations
MRD conversion is considered a strong predictor of event-free survival; a 30% difference is seen as clinically meaningful.
About one-fifth of patients are estimated to be MRD positive after frontline treatment, aligning with enrollment projections.
MRD testing is performed within one to three months post-R-CHOP, consistent with published standards.
Adoption of MRD testing is increasing in both hematology and solid tumors, supporting broader clinical use.
The Alpha3 study is designed to improve cure rates, not just event-free survival, in large B-cell lymphoma.
Autoimmune program and pipeline development
ALLO-329 is a dual CAR-T targeting CD19 and CD70, designed to address both B-cell and T-cell driven autoimmune diseases.
Phase I basket study is enrolling patients with lupus, myositis, and scleroderma, using two parallel cohorts with different lymphodepletion strategies.
Initial data in the first half of next year will focus on CAR-T expansion, biomarker changes, and early clinical responses.
CD70 targeting may enable longer remissions and expansion into T-cell driven autoimmune indications such as type 1 diabetes and multiple sclerosis.
Further development decisions on dose and lymphodepletion will require more patient data.
How does outpatient dosing impact Alpha-3 trial?
What T-cell driven diseases could ALLO-329 target?
What is the COGS advantage of allogeneic CAR-T?
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Next Allogene Therapeutics earnings date
Q4 202513 Mar, 2026
Next Allogene Therapeutics earnings date
Q4 202513 Mar, 2026
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Frequently asked questions
Allogene Therapeutics Inc is a biotechnology company focused on developing allogeneic CAR T cell therapies for cancer treatment. The company’s approach uses gene-editing and cell engineering technologies to produce off-the-shelf immunotherapies designed to target various hematologic and solid tumors. Its operations span research, clinical trials, and manufacturing. Allogene Therapeutics Inc is headquartered in South San Francisco, California, and its shares are listed on the NASDAQ.
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