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Edge12 Dec 2025
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The story of how a Swiss runner's pursuit of a new running sensation became On, aiming to be the most premium global sportswear brand worldwide.
ALX Oncology
ALX Oncology (ALXO) investor relations material
ALX Oncology 44th Annual J.P. Morgan Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.44th Annual J.P. Morgan Healthcare Conference summary15 Jan, 2026
Key strategic updates and forward-looking statements
Advancing two novel cancer therapies, Evorpacept and ALX2004, with multiple clinical milestones expected in 2026.
Forward-looking statements include expectations for clinical trial results, regulatory approvals, and financial performance.
Projected cash runway extends into Q1 2027, supporting key milestones such as ALX2004 safety data and ASPEN-Breast trial results.
Ongoing collaborations with Jazz Pharmaceuticals and Sanofi to expand clinical programs.
Clinical development highlights
Evorpacept demonstrated significant efficacy in HER2+ CD47-high gastric cancer, with 65% ORR and improved survival metrics in ASPEN-06.
Jazz collaboration showed 56% ORR in HER2+ breast cancer patients post-Enhertu.
Sanofi collaboration advanced multiple myeloma trial to dose optimization phase.
ALX2004, a differentiated EGFR ADC, is in phase 1 dose escalation with promising preclinical safety and efficacy.
Mechanism of action and biomarker strategy
Evorpacept blocks CD47-SIRPA interaction, enhancing macrophage-mediated phagocytosis when combined with anti-cancer antibodies.
Inactive Fc design of Evorpacept minimizes toxicity compared to conventional CD47 blockers.
CD47 overexpression is a negative prognostic biomarker across multiple tumor types, supporting patient selection strategies.
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Next ALX Oncology earnings date
Q4 20255 Mar, 2026
ALX Oncology
Next ALX Oncology earnings date
Q4 20255 Mar, 2026
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Frequently asked questions
ALX Oncology Holdings Inc. is a clinical-stage immuno-oncology company focused on developing therapies that target the CD47 checkpoint pathway, which plays a critical role in cancer cells' ability to evade the immune system. The company's lead product candidate, evorpacept, is designed to block CD47 and is being developed in combination with other anti-cancer agents. The company is headquartered in South San Francisco, California, and its shares are listed on the NASDAQ.
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