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Annexin Pharmaceuticals (ANNX) investor relations material
Annexin Pharmaceuticals Life Science Summit 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Company overview and scientific foundation
Focuses on ophthalmology, particularly retinal diseases, with some oncology work ongoing but not discussed here.
Based in Stockholm, leveraging science from Karolinska, Inserm, and internal IP, especially in CMC.
Lead candidate is Annex V, a modified form of Annexin A5, aiming to be first-in-class for eye disease.
Clinical development and differentiation
Demonstrates disease-modifying potential, aiming to halt chronic progression in eye diseases.
Currently analyzing phase 2A data and preparing for a phase 2B trial, seeking partner financing.
Targets upstream mechanisms in retinal diseases, potentially eliminating the need for current therapies like anti-VEGF.
Clinical results and patient impact
Phase 2A data show strong safety and positive efficacy signals in retinal vein occlusion (RVO).
Treatment led to rapid, durable effects and significant reduction in anti-VEGF injections needed.
Visual acuity and fluid reduction in the eye were durable, with some patients needing no anti-VEGF.
Blood flow in the retina improved and stabilized after treatment, a unique mechanistic finding.
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