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Annexin Pharmaceuticals (ANNX) investor relations material

Annexin Pharmaceuticals Life Science Summit 2025 summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Life Science Summit 2025 summary17 Nov, 2025

Company overview and scientific foundation

  • Focuses on ophthalmology, particularly retinal diseases, with some oncology work ongoing but not discussed here.

  • Based in Stockholm, leveraging science from Karolinska, Inserm, and internal IP, especially in CMC.

  • Lead candidate is Annex V, a modified form of Annexin A5, aiming to be first-in-class for eye disease.

Clinical development and differentiation

  • Demonstrates disease-modifying potential, aiming to halt chronic progression in eye diseases.

  • Currently analyzing phase 2A data and preparing for a phase 2B trial, seeking partner financing.

  • Targets upstream mechanisms in retinal diseases, potentially eliminating the need for current therapies like anti-VEGF.

Clinical results and patient impact

  • Phase 2A data show strong safety and positive efficacy signals in retinal vein occlusion (RVO).

  • Treatment led to rapid, durable effects and significant reduction in anti-VEGF injections needed.

  • Visual acuity and fluid reduction in the eye were durable, with some patients needing no anti-VEGF.

  • Blood flow in the retina improved and stabilized after treatment, a unique mechanistic finding.

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Frequently asked questions

Annexin Pharmaceuticals AB is a Swedish biotechnology company focused on developing innovative therapies for cardiovascular and inflammatory diseases. Its lead product, ANXV, is a recombinant human protein, Annexin A5, which has the potential to treat conditions related to blood vessel damage and inflammation. The drug is currently undergoing clinical trials, particularly for Retinal Vein Occlusion (RVO), a condition that can lead to vision loss, and shows potential for broader applications, including in oncology. The company is headquartered in Stockholm, Sweden, and its shares are listed on the Stockholm Stock Exchange.

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