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Antengene Corporation (6996) investor relations material
Antengene Corporation H1 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H1 2025 earnings summary22 Aug, 2025
Executive summary
Achieved key clinical milestones in 2025, including Breakthrough Therapy Designation for ATG-022 (CLDN18.2 ADC) in gastric cancer and expansion of the pipeline in solid tumors and autoimmune diseases.
Revenue for the six months ended June 30, 2025, was RMB53.2 million, down year-over-year but up sequentially, reflecting stabilization after initial NRDL-driven growth.
Loss for the period narrowed significantly to RMB76.4 million from RMB167.0 million year-over-year, with adjusted loss at RMB72.9 million, driven by reduced R&D, selling, and administrative expenses.
Major pipeline progress included new approvals and reimbursement for XPOVIO® (selinexor) in multiple APAC markets and clinical advancements for several assets.
Demonstrated strong efficacy and safety data for lead assets, particularly ATG-022 and ATG-037, with durable responses and favorable safety profiles in difficult-to-treat cancers.
Financial highlights
Revenue: RMB53.2 million (down from RMB60.8 million year-over-year), gross profit: RMB42.9 million, and other income and gains: RMB38.1 million, mainly from increased government grants.
R&D costs: RMB79.9 million (down from RMB130.8 million year-over-year), selling and distribution expenses: RMB37.0 million, administrative expenses: RMB39.3 million.
Loss for the period: RMB76.4 million (down from RMB167.0 million year-over-year); adjusted loss: RMB72.9 million (down from RMB152.6 million year-over-year).
Cash and bank balances: RMB794.1 million as of June 30, 2025.
Targeting over US$5 billion in peak sales for ATG-022 in gastric cancer, not including potential in other CLDN18.2+ tumors.
Outlook and guidance
Ongoing Phase I/II and Phase Ib/II trials for ATG-022 in combination with pembrolizumab and CAPOX in advanced/metastatic gastric cancer, aiming for label expansion.
Continued advancement of 9 clinical stage products across oncology and autoimmune diseases, with focus on expanding commercial team for XPOVIO® launches in APAC.
Ongoing investment in AI-driven R&D and next-generation T-cell engager platform.
IND submissions planned for first-in-class TCEs (ATG-106, ATG-110) in 2027, with continued focus on expanding into new tumor types and autoimmune indications.
Unutilized IPO net proceeds of RMB376.61 million expected to be fully used by end-2026.
XPOVIO revenue outlook post-NRDL normalization?
R&D cost reduction impact on pipeline progress?
How will AI department accelerate TCE pipeline?
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Next Antengene Corporation earnings date
H2 202519 Mar, 2026
Next Antengene Corporation earnings date
H2 202519 Mar, 2026
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Frequently asked questions
Antengene Corporation Limited is a China-based biotechnology company focused on the discovery, development, and commercialization of therapies for cancer and other life-threatening diseases. Antengene's work spans early-stage discovery through clinical development and regulatory approvals, with a focus on targeted therapies and immuno-oncology. It is headquartered in Shanghai, China, and its shares are listed on the HKEX.
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