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Visual21 Nov 2025
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Ardelyx (ARDX) investor relations material
Ardelyx Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary19 Nov, 2025
Business overview and product franchises
Focus on developing small molecule drugs for GI tract, with two main franchises: IBSRELA for IBS-C and XPHOZAH for hyperphosphatemia.
Both products have shown consistent quarter-over-quarter growth in demand and revenue.
IBSRELA is positioned as a billion-dollar opportunity, targeting a large, unsatisfied patient population.
XPHOZAH is contributing positively to the product P&L and is expected to grow further.
Commercial performance and market strategy
Sales force expansion has increased reach to about 50% of the TRX market, covering 14,000 physicians.
Field access manager team expansion improved patient access and approval rates for IBSRELA.
IBSRELA offers a differentiated therapy, with 80% patient satisfaction compared to 23% for secretagogues.
Marketing and patient engagement drive high conversion rates when patients request IBSRELA by name.
Market size, growth outlook, and guidance
Over 6 million prescriptions for IBS-C annually, with double-digit market growth over three years.
Path to $1 billion in IBSRELA sales requires about 200,000 patients, leveraging dissatisfaction with current therapies.
Patent runway extends to 2032-2033, with no direct competitors currently in the market.
Sales force productivity expected to remain high, with ongoing optimization but no major expansion planned.
Beyond current efforts, how to accelerate IBSRELA to $1B?
How will XPHOZAH achieve $750M post-TDAPA?
What is the primary strategic focus for 531 development?
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Q4 202527 Feb, 2026
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Frequently asked questions
Ardelyx Inc is a biopharmaceutical company engaged in discovering, developing, and commercializing novel treatments for patients with gastrointestinal and cardiorenal diseases. Their approach focuses on creating targeted, first-in-class, oral, small molecule therapies that address significant unmet medical needs. The company's flagship product candidate is tenapanor, aimed at treating irritable bowel syndrome with constipation. Furthermore, Ardelyx is advancing XPHOZAH in Phase III clinical trials for controlling serum phosphorus in patients with chronic kidney disease on dialysis, and other product candidates like RDX013 and RDX020 target hyperkalemia and metabolic acidosis, respectively. Ardelyx has formed strategic partnerships with Kyowa Kirin, Fosun Pharmaceutical Industrial Development Co. Ltd., and Knight Therapeutics, Inc. for the development and commercialization of tenapanor in various territories. Originally founded as Nteryx, Inc., the company rebranded to Ardelyx, Inc. in 2008 and is headquartered in Waltham, Massachusetts, with its shares listed on the NASDAQ.
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