Arrowhead Pharmaceuticals
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Arrowhead Pharmaceuticals (ARWR) investor relations material

Arrowhead Pharmaceuticals H.C. Wainwright 28th Annual Global Investment Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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H.C. Wainwright 28th Annual Global Investment Conference summary16 Sep, 2026

Platform and pipeline overview

  • Developed a broad RNAi platform targeting multiple cell types, with five represented in clinical candidates.

  • Transitioned to a commercial stage with 21–22 drug candidates in clinical studies.

  • Plans to access a new cell type every 18–24 months, expanding beyond liver to CNS and other tissues.

  • Focused on building a broad-based company addressing diverse indications.

REDEMPLO (plozasiran) launch and expansion

  • REDEMPLO approved for FCS, targeting both genetic and clinically defined FCS populations.

  • Contracting with payers established; sales force expanded to address larger clinical FCS population.

  • Preparing for SHTG launch in Q2 2027, with further sales force growth planned in early 2027.

SHASTA-3 and SHASTA-4 trial results

  • Achieved ~80% reduction in triglycerides in severe hypertriglyceridemia patients.

  • Statistically significant reduction in acute pancreatitis risk, with 78–100% risk reduction in high-risk subgroups.

  • Clean safety profile: no significant liver, hypersensitivity, or thrombocytopenia issues; no increase in liver fat.

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Q4 202625 Nov, 2026
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