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Arrowhead Pharmaceuticals (ARWR) investor relations material
Arrowhead Pharmaceuticals H.C. Wainwright 28th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Platform and pipeline overview
Developed a broad RNAi platform targeting multiple cell types, with five represented in clinical candidates.
Transitioned to a commercial stage with 21–22 drug candidates in clinical studies.
Plans to access a new cell type every 18–24 months, expanding beyond liver to CNS and other tissues.
Focused on building a broad-based company addressing diverse indications.
REDEMPLO (plozasiran) launch and expansion
REDEMPLO approved for FCS, targeting both genetic and clinically defined FCS populations.
Contracting with payers established; sales force expanded to address larger clinical FCS population.
Preparing for SHTG launch in Q2 2027, with further sales force growth planned in early 2027.
SHASTA-3 and SHASTA-4 trial results
Achieved ~80% reduction in triglycerides in severe hypertriglyceridemia patients.
Statistically significant reduction in acute pancreatitis risk, with 78–100% risk reduction in high-risk subgroups.
Clean safety profile: no significant liver, hypersensitivity, or thrombocytopenia issues; no increase in liver fat.
- Breakthrough dual gene knockdown, robust triglyceride therapy, and pipeline innovation drive growth.ARWR
Morgan Stanley 24th Annual Global Healthcare Conference - Strong efficacy, safety, and launch readiness position plozasiran for high-impact SHTG entry.ARWR
12th Annual Cantor Fitzgerald Global Healthcare Conference - Plozasiran delivers robust, sustained efficacy and safety for high-risk SHTG patients.ARWR
KOL event - SHASTA-3/4 trials drove strong efficacy, revenue growth, and global REDEMPLO expansion.ARWR
Q3 2026 - Plozasiran nears launch after robust phase III data, with lung program readouts expected soon.ARWR
Chardan's 8th Annual Genetic Medicines Conference - ARO-INHBE plus tirzepatide doubled weight loss and tripled fat reduction in obese diabetics.ARWR
Study Update - FDA approval, record revenue, and global licensing deals mark a pivotal commercial milestone.ARWR
Q4 2025 - FDA approved Redemplo after Phase 3 data showed 80% triglyceride reduction in FCS patients.ARWR
Study Result - Q2 FY2025 saw $542.7M revenue, $370.4M net income, and funding secured into 2028.ARWR
Q2 2025
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