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Artiva Biotherapeutics (ARTV) investor relations material
Artiva Biotherapeutics Cantor Global Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Program overview and technology
Focused on non-genetically modified NK cell therapies, combined with monoclonal antibodies for enhanced ADCC and B cell killing.
NK cells sourced from umbilical cord units, enabling large-scale, long-shelf-life, infusion-ready products.
Therapy is designed for rapid IV administration and offers a safety profile superior to T cell-based modalities.
Clinical work has shifted from oncology to autoimmunity, with multiple ongoing trials in various indications.
Differentiation and competitive landscape
Emphasizes high efficacy and safety, aiming for compatibility with community-based administration.
Seeks to outperform monoclonal antibodies and align with or exceed the best standard of care in each indication.
Prior oncology trials demonstrated high complete response rates and durability, supporting confidence in autoimmunity applications.
Flexibility in dosing allows for repeat treatments, distinguishing from more intensive CAR T regimens.
Regimen components and safety considerations
Regimen includes cyclophosphamide, fludarabine, rituximab, and allo NK cells, with low doses of CyFlu to minimize risk.
CyFlu is used to prevent immune rejection and enable NK cell persistence, with transient effects on immune cells.
Safety profile is being closely monitored, with optional prophylactic antibiotics and antivirals to address infection risk.
Target product profile aims for outpatient and community setting compatibility, minimizing hospitalization and severe adverse events.
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