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Assembly Biosciences (ASMB) investor relations material

Assembly Biosciences Guggenheim Securities 2nd Annual Healthcare Innovation Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Guggenheim Securities 2nd Annual Healthcare Innovation Conference summary12 Nov, 2025

Company overview and recent developments

  • Transitioned from HBV-focused to a broader herpes virus company, now leading with two compounds for recurrent genital herpes in phase 1b trials.

  • Pipeline includes 5366 and 1179 for genital herpes, a Hep Delta molecule moving to phase 2, and an HBV asset with Gilead opt-in potential.

  • Four assets are currently in clinical development, with recent positive data for 5366.

Unmet need and market opportunity in genital herpes

  • Current standard of care (valacyclovir/Valtrex) leaves two-thirds of patients with recurrences annually.

  • Existing treatments require daily dosing; new candidates aim for once-weekly or even monthly regimens.

  • Market analysis estimates over 1.3 million recurrent genital herpes patients in the US, with a multi-billion dollar market potential.

Lead programs: 5366 and 1179

  • 5366 is a helicase-primase inhibitor, 400x more potent than valacyclovir, with a 20-day half-life.

  • 1179, sourced from Gilead, is 1,000x more potent than valacyclovir, with a four-day half-life.

  • Both are designed for long-acting oral or injectable use and are in phase 1b trials.

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Frequently asked questions

Assembly Biosciences, Inc. is a biopharmaceutical company focused on developing small molecule antiviral therapeutics. It is primarily engaged in the discovery and development of treatments targeting hepatitis B virus (HBV) and hepatitis delta virus (HDV), including a portfolio of HBV core inhibitors and other novel antiviral compounds aimed at managing chronic infections. Additionally, the company explores therapies for herpesviruses, with programs advancing long-acting inhibitors and other non-nucleoside polymerase inhibitors intended for transplant-associated infections and other serious disease conditions. Assembly Biosciences is headquartered in South San Francisco, California, and its shares are listed on the NASDAQ.

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