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Assembly Biosciences (ASMB) investor relations material
Assembly Biosciences Guggenheim Securities 2nd Annual Healthcare Innovation Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Company overview and recent developments
Transitioned from HBV-focused to a broader herpes virus company, now leading with two compounds for recurrent genital herpes in phase 1b trials.
Pipeline includes 5366 and 1179 for genital herpes, a Hep Delta molecule moving to phase 2, and an HBV asset with Gilead opt-in potential.
Four assets are currently in clinical development, with recent positive data for 5366.
Unmet need and market opportunity in genital herpes
Current standard of care (valacyclovir/Valtrex) leaves two-thirds of patients with recurrences annually.
Existing treatments require daily dosing; new candidates aim for once-weekly or even monthly regimens.
Market analysis estimates over 1.3 million recurrent genital herpes patients in the US, with a multi-billion dollar market potential.
Lead programs: 5366 and 1179
5366 is a helicase-primase inhibitor, 400x more potent than valacyclovir, with a 20-day half-life.
1179, sourced from Gilead, is 1,000x more potent than valacyclovir, with a four-day half-life.
Both are designed for long-acting oral or injectable use and are in phase 1b trials.
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