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Aura Biosciences (AURA) investor relations material

Aura Biosciences H.C. Wainwright 27th Annual Global Investment Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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H.C. Wainwright 27th Annual Global Investment Conference summary10 Sep, 2025

Innovation and clinical development

  • Developing a novel class of virus-like drug conjugates (VDCs) for targeted cancer therapy in ocular and urologic oncology.

  • Lead candidate AU-011 (bel-sar) is in late-stage clinical trials for early choroidal melanoma, with a SPA agreement supporting registration.

  • Additional indications in ocular oncology (metastasis to the choroid, ocular surface cancers) are advancing through phase 2 and phase 1 trials.

  • VDCs offer high selectivity, potent tumor ablation, and immune activation, with low risk of resistance.

  • Platform potential extends to both ocular and non-ocular solid tumors.

Key milestones and financial outlook

  • Next milestones include completion of phase 3 enrollment for choroidal melanoma and data from the bladder cancer study.

  • Cash runway extends into the first half of 2027, supporting ongoing and planned clinical programs.

  • Ocular oncology pipeline targets over three indications, all addressable with the same VDC technology.

Ocular oncology opportunity

  • Ocular oncology represents a rare disease market with 66,000 patients lacking effective treatments.

  • VDCs can treat multiple ocular cancers with a single technology, aiming to replace surgery and radiotherapy.

  • Early choroidal melanoma patients currently face limited options, often resorting to watchful waiting or radiotherapy with high comorbidities.

  • VDC therapy offers a non-invasive, vision-preserving alternative, aiming to disrupt the current standard of care.

  • Phase 2 data show 80% tumor control and 90% vision preservation at 12 months, supporting high probability of phase 3 success.

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Frequently asked questions

Aura Biosciences Inc. is a biotechnology company focused on developing therapies for cancer treatment. It specializes in the creation of virus-like drug conjugates (VDC) technology, aiming to address tumors with significant unmet medical needs in ocular and urologic oncology. A key development in their portfolio is AU-011, a VDC candidate targeting primary choroidal melanoma. The company also explores the potential of AU-011 for other ocular oncology indications, including choroidal metastases, and is conducting Phase 2 dose-escalation trials. Aura Biosciences is headquartered in Cambridge, Massachusetts, and its shares are listed on the NASDAQ.

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