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Aura Biosciences (AURA) investor relations material
Aura Biosciences H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Innovation and clinical development
Developing a novel class of virus-like drug conjugates (VDCs) for targeted cancer therapy in ocular and urologic oncology.
Lead candidate AU-011 (bel-sar) is in late-stage clinical trials for early choroidal melanoma, with a SPA agreement supporting registration.
Additional indications in ocular oncology (metastasis to the choroid, ocular surface cancers) are advancing through phase 2 and phase 1 trials.
VDCs offer high selectivity, potent tumor ablation, and immune activation, with low risk of resistance.
Platform potential extends to both ocular and non-ocular solid tumors.
Key milestones and financial outlook
Next milestones include completion of phase 3 enrollment for choroidal melanoma and data from the bladder cancer study.
Cash runway extends into the first half of 2027, supporting ongoing and planned clinical programs.
Ocular oncology pipeline targets over three indications, all addressable with the same VDC technology.
Ocular oncology opportunity
Ocular oncology represents a rare disease market with 66,000 patients lacking effective treatments.
VDCs can treat multiple ocular cancers with a single technology, aiming to replace surgery and radiotherapy.
Early choroidal melanoma patients currently face limited options, often resorting to watchful waiting or radiotherapy with high comorbidities.
VDC therapy offers a non-invasive, vision-preserving alternative, aiming to disrupt the current standard of care.
Phase 2 data show 80% tumor control and 90% vision preservation at 12 months, supporting high probability of phase 3 success.
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