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Avacta Group (AVCT) investor relations material
Avacta Group Study Update summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Study Update summary17 Dec, 2025
Mechanism and Platform Overview
AVA6000 (faridoxorubicin) uses a FAP-activated drug delivery system to target doxorubicin release within tumors, minimizing systemic toxicity and enabling prolonged treatment.
The bystander effect allows released drug to affect both FAP-positive and adjacent tumor cells, enhancing tumor exposure while limiting blood exposure.
The pre|CISION® platform enables tumor-specific release of doxorubicin via FAP cleavage, supporting broad applicability even in low-FAP tumors.
Study Design and Patient Population
Phase 1a and 1b trials enrolled patients with salivary gland cancers, including those with high and heterogeneous FAP expression.
Phase 1b included 22 SGC patients (median age 63), with most having prior therapy; 19 were evaluable for efficacy.
Across both phases, 30 patients treated at 250 mg/m² and above were evaluable for efficacy.
Primary endpoint was safety; secondary endpoint was efficacy by FAP level.
Safety and Tolerability
AVA6000/faridoxorubicin demonstrated a favorable safety profile, with no Grade 3/4 cardiac toxicities and low rates of severe neutropenia.
Dramatic reductions in GI and hematologic toxicities were observed compared to conventional doxorubicin.
Four patients reached maximum cycles at 550 mg/m² with no severe cardiac toxicity.
Safety profile in Phase 1b was consistent with Phase 1a, with no new safety signals.
Platform efficacy with low FAP expression
AVA6000's competitive edge in SGC treatment?
Projected median PFS for AVA6000 in SGC?
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Next Avacta Group earnings date
H2 202523 Apr, 2026
Next Avacta Group earnings date
H2 202523 Apr, 2026
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Frequently asked questions
Avacta Group PLC is a biotechnology company specializing in the development of innovative diagnostic and therapeutic solutions. The company operates in two primary segments: diagnostics, where it develops rapid tests and reagents, and therapeutics, focusing on the development of precision oncology treatments. Avacta utilizes proprietary technologies, such as its Affimer platform, to create targeted therapies and diagnostic tools. The company is headquartered in Wetherby, United Kingdom, and its shares are listed on the AIM.
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