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AVROBIO (AVRO) investor relations material
AVROBIO Q4 2024 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2024 earnings summary19 Mar, 2025
Executive summary
Transitioned to a public company in 2024 and reported positive interim results from TX45 Phase 1b trial in PH-HFpEF patients, supporting ongoing Phase 2 APEX trial endpoints and population.
Enrolled first subject in TX45 Phase 1b Part B trial for HFrEF in March 2025; topline results expected 2H 2025.
Completed $185M private placement in February 2025, extending cash runway into Q4 2028.
Financial highlights
Cash and cash equivalents were $141.2M as of December 31, 2024, down from $159.1M at September 30, 2024.
Research and development expenses rose to $9.2M in Q4 2024 from $7.1M in Q4 2023, mainly due to increased clinical and manufacturing activities.
General and administrative expenses increased to $4.8M in Q4 2024 from $2.3M in Q4 2023, reflecting higher costs as a public company.
Net loss for Q4 2024 was $12.4M, compared to $7.9M in Q4 2023; full-year net loss was $58.0M versus $42.8M in 2023.
Outlook and guidance
Cash position, including proceeds from the private placement, expected to fund operations through key TX45 Phase 1b/2 readouts and TX2100 clinical development into Q4 2028.
TX45 Phase 1b Part B topline results anticipated in 2H 2025; APEX Phase 2 topline results expected in 2026.
TX2100 Phase 1 trial for HHT planned to initiate in Q4 2025 or Q1 2026, pending completion of IND-enabling studies.
Assess TX45's competitive advantages.
Explain the TX2100 target GPCR rationale.
Detail the use of PIPE financing proceeds.
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Frequently asked questions
AVROBIO, Inc. is a clinical-stage biotechnology company specializing in the development of gene therapies using a lentiviral-based platform. These therapies are designed to treat rare diseases with a single dose, and involve modifying hematopoietic stem cells extracted from patients. AVROBIO focuses on a range of genetic disorders, employing its proprietary plato® platform to optimize these therapies. Notable diseases targeted by AVROBIO's gene therapies include Gaucher disease, Pompe disease, cystinosis, and Hunter syndrome, with several treatments in various stages of clinical trials. The company was established in 2015 and is based in Cambridge, Massachusetts. Its shares are listed on the NASDAQ.
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