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AVROBIO (AVRO) investor relations material
AVROBIO Q4 2024 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Transitioned to a public company in 2024 and reported positive interim results from TX45 Phase 1b trial in PH-HFpEF patients, supporting ongoing Phase 2 APEX trial endpoints and population.
Enrolled first subject in TX45 Phase 1b Part B trial for HFrEF in March 2025; topline results expected 2H 2025.
Completed $185M private placement in February 2025, extending cash runway into Q4 2028.
Financial highlights
Cash and cash equivalents were $141.2M as of December 31, 2024, down from $159.1M at September 30, 2024.
Research and development expenses rose to $9.2M in Q4 2024 from $7.1M in Q4 2023, mainly due to increased clinical and manufacturing activities.
General and administrative expenses increased to $4.8M in Q4 2024 from $2.3M in Q4 2023, reflecting higher costs as a public company.
Net loss for Q4 2024 was $12.4M, compared to $7.9M in Q4 2023; full-year net loss was $58.0M versus $42.8M in 2023.
Outlook and guidance
Cash position, including proceeds from the private placement, expected to fund operations through key TX45 Phase 1b/2 readouts and TX2100 clinical development into Q4 2028.
TX45 Phase 1b Part B topline results anticipated in 2H 2025; APEX Phase 2 topline results expected in 2026.
TX2100 Phase 1 trial for HHT planned to initiate in Q4 2025 or Q1 2026, pending completion of IND-enabling studies.
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