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Axsome Therapeutics (AXSM) investor relations material

Axsome Therapeutics TD Cowen's 5th Annual Novel Mechanisms in Neuropsychiatry & Epilepsy Summit summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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TD Cowen's 5th Annual Novel Mechanisms in Neuropsychiatry & Epilepsy Summit summary17 Sep, 2025

Commercial performance and strategy

  • Q2 net sales reached $150 million, with Auvelity contributing $120 million and Sanofi $30 million; Symbravo launched with $400,000 in initial sales.

  • Expansion of the sales force and improved coverage led to weekly MBRXs rising from 2,000 to 2,500, with 28 million additional lives covered as of July 1.

  • National direct-to-consumer campaign for Auvelity launched, expected to drive further growth in the second half of the year.

  • Symbravo's launch focused on headache specialists, with positive early feedback and a disciplined investment approach.

  • Field force expansion is planned for 2026, targeting primary care and long-term care markets.

Product utilization and market access

  • About 50% of Auvelity use is in first line or first switch, with over 50% as monotherapy, reflecting earlier adoption in the treatment paradigm.

  • Coverage improvements have facilitated easier access and maintained net pricing, with 83% of lives now covered and potential for further increases.

  • Seasonal trends impact Q3, but expectations are for growth to resume post-Labor Day as coverage and campaigns take effect.

Research and development pipeline

  • sNDA for AXS-05 in Alzheimer’s disease agitation filed in Q3, with FDA acceptance decision pending; NDA for AXS-12 in narcolepsy planned for Q4.

  • Four clinical programs for Sunosi are ongoing, with new trials in ADHD, major depressive disorder, binge eating disorder, shift work disorder, fibromyalgia, and smoking cessation planned.

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Frequently asked questions

Axsome Therapeutics Inc. is a biopharmaceutical company focused on developing and commercializing therapies for central nervous system (CNS) disorders. The company's portfolio includes product candidates designed to address conditions such as depression, migraines, and other neurological and psychiatric disorders. The company is headquartered in New York, New York, and its shares are listed on the NASDAQ.

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