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Edge12 Dec 2025
Running on Clouds: The Story of On
The story of how a Swiss runner's pursuit of a new running sensation became On, aiming to be the most premium global sportswear brand worldwide.
BeOne Medicines
BeOne Medicines (ONC) investor relations material
BeOne Medicines 44th Annual J.P. Morgan Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.44th Annual J.P. Morgan Healthcare Conference summary13 Jan, 2026
Industry impact and innovation
Significant progress in cancer treatment over the past decades, with new therapeutic modalities now central to care.
Cancer survival rates have improved over 25 years, but significant unmet needs remain, especially in hard-to-treat cancers like pancreatic and liver cancer.
Recent years have seen rapid innovation in oncology, including immuno-oncology, gene therapy, bispecifics, mRNA, cell therapy, radiopharmaceuticals, ADCs, degraders, covalent molecules, and siRNA.
Commitment to relentless innovation and speed, highlighted by a focus on improving patient outcomes and survival rates.
Despite progress, cancer continues to cause millions of deaths annually, underscoring the need for continued innovation.
Clinical data and therapeutic advancements
BRUKINSA demonstrated superior long-term outcomes in CLL, with six-year PFS and OS rates of 74% and 84%, respectively.
Only Brukinsa demonstrated progression-free survival (PFS) superiority to ibrutinib in head-to-head trials.
New combinations, such as BRUKINSA plus sonrotoclax, show rapid, deep responses and may redefine fixed-duration therapy.
First-in-class BTK CDAC offers promising results for relapsed CLL, with high response rates and broad mutation coverage.
Multiple solid tumor programs achieved proof of concept, expanding the late-stage pipeline.
Financial performance and operational excellence
Achieved significant product revenue growth in the first three quarters of 2025, with $3.8B in revenue, up 43% year-over-year.
Reported GAAP profitability with diluted earnings per ADS of $1.96 and generated $562M in free cash flow.
Generated over $350 million in free cash flow in Q3 and maintains over $4 billion in cash.
Integrated in-house R&D and manufacturing enable rapid clinical development and global trial execution.
Achieved record patient enrollment and regulatory filings, leveraging a global infrastructure.
ZS fixed duration: What market share impact
Which POC assets drive next wave of innovation?
How does global superhighway accelerate pipeline?
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Next BeOne Medicines earnings date
Q4 202515 Apr, 2026
BeOne Medicines
Next BeOne Medicines earnings date
Q4 202515 Apr, 2026
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Frequently asked questions
BeiGene Ltd. is a biotechnology company focused on the discovery, development, and commercialization of innovative oncology treatments. Established in 2010, BeiGene has expanded its operations globally, with a significant presence in markets including the United States, China, Europe, and Australia. The company's product portfolio includes a range of treatments targeting various cancers such as blood cancers, solid tumors, and myelodysplastic syndromes. BeiGene is also actively involved in collaborative projects with other pharmaceutical companies to enhance its research and development capabilities. The company is headquartered in Grand Cayman, Cayman Islands, and its shares are listed on the NASDAQ.
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