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Edge20 Mar 2026
Tetra Pak: The Shape of Innovation
The story of Tetra Pak, the Rausing family, and how a paper tetrahedron gave rise to a company that now delivers almost 180 billion packages a year.
Bicara Therapeutics
Bicara Therapeutics (BCAX) investor relations material
Bicara Therapeutics Barclays 28th Annual Global Healthcare Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Barclays 28th Annual Global Healthcare Conference summary10 Mar, 2026
Company overview and scientific rationale
Focuses on bifunctional antibodies targeting tumors, with a lead EGFR TGF-beta program licensed in 2020.
EGFR is used to deliver TGF-beta to the tumor microenvironment, exploiting synergy between the two.
HPV-negative head and neck cancer is a primary target due to high EGFR and TGF-beta expression.
TGF-beta helps overcome acquired resistance to EGFR, providing dual mechanism benefits.
Clinical data and efficacy
Early data showed deep and durable responses, with a 21% complete response rate at 1500 mg and 55% confirmed response rate.
Median duration of response is 21.7 months, nearly tripling the responder population compared to Pembro.
TGF-beta component is credited for enhanced depth and durability of response.
Durability and efficacy are consistent across multiple dosing regimens.
Safety and differentiation
Improved toxicity profile attributed to a more targeted TGF-beta trap using the extracellular domain of receptor two.
Greater specificity for TGF-beta 1 and 3 reduces historical toxicities like cardiomyopathy.
FICERA TGF-beta receptor 2 safety profile
FICERA Project Front Runner regulatory path
FICERA maintenance dosing and pembro sync
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Latest events from Bicara Therapeutics
- FICERA demonstrates robust efficacy in head and neck cancer, with global trial momentum and 2028 launch planned.BCAX
TD Cowen 46th Annual Health Care Conference3 Mar 2026 - FICERA delivers deep, durable responses and survival benefit in HPV-negative HNSCC.BCAXCorporate presentation2 Mar 2026
- 48% response and 26% CR rates with deep, durable responses and strong safety at flexible dosing.BCAXStudy update23 Feb 2026
- FICERA delivers deep, durable responses in HPV-negative HNSCC, doubling survival rates.BCAXCorporate presentation16 Jan 2026
- Lead asset shows strong efficacy in head and neck cancer; pivotal trial and expansion plans underway.BCAXStifel 2024 Healthcare Conference13 Jan 2026
- Ficerafusp alfa shows deep, durable responses and blockbuster potential in head and neck cancer.BCAX44th Annual J.P. Morgan Healthcare Conference12 Jan 2026
- Ficerafusp alfa demonstrates high response and durability in HPV-negative head and neck cancer.BCAXCantor Global Healthcare Conference 20255 Jan 2026
- Lead asset delivers significant survival gains in head and neck cancer; pivotal trial ongoing.BCAXWells Fargo 20th Annual Healthcare Conference 202531 Dec 2025
- Up to $400M in securities offered, with $150M at-the-market sales to fund clinical and R&D growth.BCAXRegistration Filing16 Dec 2025
Next Bicara Therapeutics earnings date
Q4 202530 Mar, 2026
Bicara Therapeutics
Next Bicara Therapeutics earnings date
Q4 202530 Mar, 2026
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Amina0781App Store
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