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Bicycle Therapeutics (BCYC) investor relations material
Bicycle Therapeutics Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary18 Nov, 2025
Technology platform and differentiation
Utilizes bicyclic peptides for high affinity and selectivity, mimicking antibody paratopes but with improved tissue penetration and reduced off-target effects.
Focused on next-generation targeting, especially toxin conjugates and radio conjugates, with zelenectide pevedotin as the lead molecule targeting Nectin-4.
Pipeline includes BT5528 targeting EphA2 and significant efforts in radio conjugates.
Zelenectide pevedotin (zele) in bladder cancer
Aims to match or exceed efficacy of PADCEV while significantly improving safety, reducing neuropathy and skin toxicity.
Phase I data show comparable efficacy to PADCEV but with a differentiated, improved safety profile.
Market research indicates strong physician preference for Zele Plus P if safety improvements are realized, with 84% of surveyed physicians likely to switch.
Clinical development and regulatory strategy
Seamless phase II/III trial in bladder cancer with dose optimization and regulatory endpoints; dose selection data expected Q1 2026.
Engaging with regulators in the US, UK, and Europe to align on study design and approval pathways.
Will only advance if efficacy is at least as good as, and safety better than, current standards; top-line data to be released in Q1 2026, with full data at a medical meeting later that year.
Xela's market strategy against Padcev's toxicity?
BT5528's path forward given unique safety?
Radio conjugates: specific targets and isotopes?
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Next Bicycle Therapeutics earnings date
Q4 202520 Feb, 2026
Next Bicycle Therapeutics earnings date
Q4 202520 Feb, 2026
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Frequently asked questions
Bicycle Therapeutics plc is a clinical-stage biopharmaceutical company focused on developing a novel class of medicines known as Bicycle molecules. These molecules are fully synthetic short peptides constrained by small molecule scaffolds, forming two loops that stabilize their structure. This design allows them to bind to targets with high affinity and selectivity, making them promising candidates for drug development, particularly in areas where existing therapeutics are lacking. Bicycle Therapeutics is headquartered in Cambridge, UK, with significant operations in Cambridge, Massachusetts. Its shares are listed on NASDAQ.
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