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BioCryst Pharmaceuticals
BioCryst Pharmaceuticals (BCRX) investor relations material
BioCryst Pharmaceuticals TD Cowen 46th Annual Health Care Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.TD Cowen 46th Annual Health Care Conference summary3 Mar, 2026
Financial performance and growth outlook
Achieved $601 million in revenue last year, with $563 million after divesting the European business; $214 million in non-GAAP operating profits.
U.S. now accounts for over 90% of revenue, with continued growth in Canada, Japan, and distributor markets.
2026 revenue guidance set at $625–$645 million, reflecting 13% growth over last year’s U.S.-focused baseline.
Each 1% increase in patient paid rate in 2029 is projected to add about $12 million in annualized revenue.
Portfolio expected to grow at mid-teens revenue rates into the 2030s, supported by strong patent protection.
Product launch dynamics and market penetration
ORLADEYO remains the only oral prophylactic for HAE, with about half of new patients switching from injectables and the other half new to prophylaxis.
Over 1,500 prescribers at year-end, with growth driven by community allergists rather than academic centers.
Pediatric launch for ORLADEYO pellets (ages 2+) began after December approval, with product available by early April and strong initial excitement.
Pediatric adoption forecast remains conservative due to uncertainties in uptake speed, but long-term value is expected.
ORLADEYO pellets will be priced flat with capsules and integrated into existing contracts.
Patient retention, super-responders, and competitive landscape
About 50% of clinical trial patients remained on ORLADEYO after two years, experiencing a 91% reduction in attacks.
In real-world use, 60% of patients stay on therapy after one year, with high retention among super-responders.
Super-responders experience injectable-like efficacy and are expected to remain loyal to the therapy.
New competitors like Pharvaris are anticipated, but differentiated patient preferences and product profiles are expected to sustain market share.
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Next BioCryst Pharmaceuticals earnings date
Q1 20264 May, 2026
BioCryst Pharmaceuticals
Next BioCryst Pharmaceuticals earnings date
Q1 20264 May, 2026
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Frequently asked questions
BioCryst Pharmaceuticals Inc develops and commercializes oral medications for rare and serious diseases. The company focuses on small-molecule therapeutics, including treatments for hereditary angioedema and viral infections. Its research pipeline supports expansion into additional indications. The company is headquartered in Durham, North Carolina, and its shares are listed on the NASDAQ.
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