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Company Research20 Mar 2024
Companies That Had Their IPO in 1991: Recovery From a Recession
An overview of the markets and the IPO landscape as the economy recovered from the early 90s recession.
Biogen (BIIB) investor relations material
Biogen Bernstein Insights: Healthcare Leaders and Disruptors - 2nd Annual Healthcare Forum summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Bernstein Insights: Healthcare Leaders and Disruptors - 2nd Annual Healthcare Forum summary24 Sep, 2025
Commercial and pipeline progress
Alzheimer's franchise shows growth, with LEQEMBI launch seeing key inflection points and recent approval for subcutaneous maintenance, offering patients more flexibility in treatment options.
Blood-based biomarkers are increasingly used, improving diagnosis efficiency and freeing up clinical resources.
Growth products are offsetting declines in the MS portfolio, with a focus on high-value, high-probability late-stage programs expected to yield registrational data as early as next year.
Business development includes advancing lupus assets (litifilimab, dapirolizumab pegol) and expanding into rare nephrology with Felsardimab, now in three phase 3 trials.
Strategic alliances, such as with Stoke Therapeutics, are building a robust pre-proof-of-concept pipeline with several important readouts expected next year.
Alzheimer's disease and neurology innovation
LEQEMBI, an anti-amyloid therapy with a dual mechanism, has shown sustained benefit in long-term data and now offers subcutaneous administration, with a rolling submission for initiation expected to conclude mid next year.
The CELIA study for TAU ASO (BIIB080) is set to read out mid next year, aiming to clarify the impact of TAU reduction on clinical outcomes, with ongoing exploration of improved delivery methods.
GLP-1 trials in Alzheimer's are seen as expanding awareness and may support combination therapy approaches, with anti-amyloid as a backbone.
The AHEAD 3, 4, 5 trials target pre-symptomatic Alzheimer's, using biomarker-driven endpoints and blood-based screening to address prevention and early intervention.
Rare diseases and SMA franchise
SPINRAZA remains a key therapy in SMA, with high-dose trials showing promising biomarker and clinical results; a resubmission to address technical review issues is planned soon.
Salinursin, a once-yearly antisense oligonucleotide, has shown early proof of concept and anecdotal clinical improvements, with phase 3 initiation targeted for early 2026.
AHEAD 3-45: key questions for presymptomatic AD?
R&D strategy: how does it derisk pipeline assets?
SPINRAZA high dose CRL: path to resubmission?
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Frequently asked questions
Developing Breakthrough Medications
Biogen is a multinational biotechnology company operating in the field of discovery, development, and sale of various. The company was established in 1978 and is based in Cambridge, Massachusetts. Over the years, Biogen has emerged as a key player in the biotech sector, specifically in neurology, with several therapies targeting multiple sclerosis (MS) and spinal muscular atrophy (SMA). Beyond neurology, their portfolio spans therapies for conditions such as hemophilia and other rare disorders.
Decades of Experience
Founded in 1978, Biogen stands as one of the world's oldest independent biotechnology companies. Its roots trace back to a group of scientists who recognized the potential of biotechnology to produce breakthrough medicines. In addition to its offerings of medications currently on the market, the company has consistently invested in research and development, leading to numerous innovations in the biotechnology sector. Biogen has consistently been able to develop marketable medications that make a positive impact on patient health. The company has expanded through a combination of organic growth as well as through collaborations and acquisitions over the years.
The Portfolio
Biogen has a vast therapeutic portfolio of various medications. The company has developed a range of therapies over the years, with several being first-of-their-kind or best-in-class. A standout is their focus on neurology, particularly in multiple sclerosis. Products like TECFIDERA and AVONEX have been game-changers in the MS treatment landscape. Additionally, SPINRAZA, designed for spinal muscular atrophy, is another prime example of Biogen's novel treatments addressing severe medical conditions. The company is also constantly working on developing new drugs
A Global Company
The company has a significant global presence, spanning countries across multiple continents. Their expansive distribution network ensures that their therapies are accessible to patients around the world. This is nothing unique for this type of company and the world's largest biotechnology companies and medication producers such as Pfizer, Eli Lilly, and Amgen, to mention a few, all operate on a global scale.
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