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BioMarin Pharmaceutical
BioMarin Pharmaceutical (BMRN) investor relations material
BioMarin Pharmaceutical Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary23 Feb, 2026
Executive summary
Achieved 13% year-over-year revenue growth in 2025, reaching $3.221 billion, driven by strong global demand for enzyme therapies and VOXZOGO, which grew 9% and 26% respectively.
Q4 2025 revenues rose 17% year-over-year to $875 million, with robust performance across the portfolio.
Strategic goals for 2025 were met, and 2026 is expected to see further expansion through the acquisition of Amicus Therapeutics and pipeline advancements.
Integration of Amicus assets and continued innovation are expected to accelerate revenue growth and diversify the portfolio.
Voluntary withdrawal of ROCTAVIAN resulted in significant charges impacting GAAP and Non-GAAP results.
Financial highlights
Full-year 2025 revenues reached $3.221 billion, up 13% year-over-year; Q4 revenues were $875 million, up 17%.
VOXZOGO revenue grew 26% year-over-year to $927 million; enzyme therapies revenue increased 9% to $2.105 billion.
PALYNZIQ revenue rose 25% in Q4 and 22% for the full year; ALDURAZYME up 14%, BRINEURA up 10%.
Operating cash flow for 2025 was $828 million, a 45% increase over 2024.
Full-year GAAP diluted EPS was $1.80 (down 19%); Non-GAAP diluted EPS was $3.15 (down 11%).
Outlook and guidance
2026 revenue guidance: $3.325–$3.425 billion, excluding Amicus contributions.
Enzyme therapies revenue expected at $2.225–$2.275 billion; VOXZOGO at $975 million–$1.025 billion.
Non-GAAP diluted EPS guidance for 2026 is $4.95–$5.15, with operating margin targeted at ~40%.
Q1 2026 expected to be the lowest revenue and EPS quarter due to order timing and pre-close Amicus costs.
Guidance excludes any post-close contribution from Amicus acquisition; updates expected after closing in Q2 2026.
BMN 333's path to new achondroplasia standard?
Amicus integration: expected profitability synergies?
ROCTAVIAN withdrawal: long-term financial impact
Voxzogo patient retention strategy vs. new oral therapies?
BMN 333: How to establish as new standard of care?
Amicus integration: Top-line and operational synergies?
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Next BioMarin Pharmaceutical earnings date
TD Cowen 46th Annual Health Care Conference4 Mar, 2026
BioMarin Pharmaceutical
Next BioMarin Pharmaceutical earnings date
TD Cowen 46th Annual Health Care Conference4 Mar, 2026
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Frequently asked questions
BioMarin Pharmaceutical Inc is a biotechnology company focused on developing and commercializing therapies for rare genetic diseases. Its research and product development efforts target conditions with limited treatment options, primarily in the fields of enzyme replacement and gene therapy. The company serves healthcare providers and patients worldwide through approved treatments and scientific initiatives. The company is headquartered in San Rafael, California, and its shares are listed on the NASDAQ.
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