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Biomea Fusion (BMEA) investor relations material
Biomea Fusion Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary3 Dec, 2025
Business overview and scientific approach
Focused on improving healthcare for diabetics, with expanding interest in obesity treatment.
Targeting Menin protein to stimulate beta cell production and potentially cure diabetes.
Early clinical data shows sustained A1C reduction in insulin-deficient patients, even after nine months off drug.
Developed an oral GLP-1 drug to address obesity, complementing Menin-targeted therapy.
Preclinical data indicates Menin inhibition upregulates GLP-1 and its receptors, supporting the therapeutic rationale.
Clinical trial updates and patient segmentation
Two phase II studies (COVALENT-211 and 212) will focus on severe insulin-deficient and GLP-1 responder subgroups.
Patient subgroups identified using a Swedish algorithm based on A1C, BMI, and diabetes duration.
Severe insulin-deficient subgroup represents about 25% of type 2 diabetics, with higher prevalence in Asian populations.
Plans to enroll first patients in both phase II studies in Q1.
Exploring application in type 1 diabetes in collaboration with Harvard, based on promising cell replication data.
Safety, dosing, and exposure optimization
Liver enzyme elevations at higher doses were mitigated by titration; 100 mg dose cleared by FDA.
Ongoing food effect studies to refine dosing instructions and minimize exposure variability.
New dosing guidelines expected in Q1, aiming for clear, patient-friendly instructions.
SID T2D market size and patient identification
Oral GLP-1 differentiation and development plan
Covalmenib dosing to mitigate liver enzyme risk
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Next Biomea Fusion earnings date
Q4 202531 Mar, 2026
Next Biomea Fusion earnings date
Q4 202531 Mar, 2026
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Biomea Fusion Inc. is a clinical-stage biopharmaceutical company that focuses on the discovery and development of covalent small molecule drugs. These drugs are designed to treat patients with genetically defined cancers and metabolic diseases. The company’s approach leverages covalent bonding, where a small molecule forms a permanent bond with its target protein, which may offer advantages like greater target selectivity and a more durable therapeutic response. The company is headquartered in Redwood City, California, and its shares are listed on the NASDAQ.
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