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BiomX (PHGE) investor relations material
BiomX Q2 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q2 2025 earnings summary13 Aug, 2025
Executive summary
Advanced phage-based clinical programs in cystic fibrosis (BX004) and diabetic foot osteomyelitis (BX211), with BX004 Phase 2b trial initiated and BX211 Phase 2 showing >40% wound size reduction and favorable safety profile.
BX004 Phase 1b/2a data published in Nature Communications, demonstrating ~500-fold bacterial reduction and no resistance in CF patients.
Completed acquisition of Adaptive Phage Therapeutics in March 2024, expanding the pipeline with two Phase 2 assets.
Discontinued atopic dermatitis program and paused prosthetic joint infection program to focus on CF and DFO.
High enthusiasm and accelerated enrollment for BX004 Phase 2b, with strong interest from patients, physicians, and partners.
Financial highlights
Cash and restricted cash totaled $15.2M as of June 30, 2025, down from $18M at year-end 2024, mainly due to operating activities.
Research and development expenses for Q2 2025 were $5.0M, down from $6.9M in Q2 2024, reflecting workforce reductions, lower rent, and increased grant funding.
General and administrative expenses were $2.4M for Q2 2025, down from $2.8M year-over-year, mainly due to reduced legal and professional fees.
Net loss for Q2 2025 was $6.0M, compared to net income of $4.5M in Q2 2024, primarily due to changes in fair value of warrants.
Net cash used in operating activities for the first half of 2025 was $14.8M, down from $22.6M in the same period of 2024.
Outlook and guidance
Cash runway expected to fund operations into Q1 2026; additional capital will be needed for longer-term operations.
Topline results from BX004 Phase 2b in CF expected in Q1 2026; FDA feedback on real-world evidence approach anticipated in H2 2025.
Planning for BX211 registrational study is underway, pending FDA discussions and continued collaboration with the US Defense Health Agency.
No significant product revenue expected in the next twelve months; continued losses anticipated.
What is the status of BX211 discussions with the Defense Health Agency?
What real-world evidence is being gathered for BX004 FDA feedback?
When is the expected timing for BX004 Phase IIb top line results?
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Frequently asked questions
BiomX Inc. is a clinical-stage biotechnology company specializing in the development of both natural and engineered phage therapies. These therapies are designed to target and eliminate specific harmful bacteria, particularly those involved in chronic diseases. The company's key focus areas include conditions like cystic fibrosis, atopic dermatitis, inflammatory bowel disease, primary sclerosing cholangitis, and colorectal cancer. BiomX utilizes its proprietary phage technology to discover and validate bacterial targets, subsequently customizing phage compositions to combat these targets effectively. The company is headquartered in Ness Ziona, Israel, and its shares are listed on the NYSE.
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