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Black Diamond Therapeutics (BDTX) investor relations material

Black Diamond Therapeutics Q2 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q2 2025 earnings summary7 Aug, 2025

Executive summary

  • Entered a global licensing agreement with Servier for BDTX-4933, receiving a $70M upfront payment and eligibility for up to $710M in milestones and tiered royalties.

  • Lead program silevertinib advanced in Phase 2 trials for EGFRm NSCLC and GBM, with key data readouts expected in late 2025 and 2026.

  • Completed enrollment for Phase 2 silevertinib trial in 1L non-classical EGFRm NSCLC (n=43); ORR and preliminary DOR data expected Q4 2025.

  • Corporate restructuring and operational efficiencies led to significant reductions in R&D and G&A expenses year-over-year.

  • Cash, cash equivalents, and investments of $142.8M as of June 30, 2025, expected to fund operations into Q4 2027.

Financial highlights

  • Reported $70M in license revenue for the six months ended June 30, 2025, compared to none in the prior year period.

  • Net income of $46.0M for the six months ended June 30, 2025, versus a net loss of $38.1M year-over-year.

  • R&D expenses decreased to $19.8M from $26.1M, and G&A expenses fell to $9.1M from $16.3M for the six-month period.

  • Net loss for Q2 2025 was $10.6M, compared to $19.9M in Q2 2024.

  • Cash position increased to $142.8M at June 30, 2025, from $98.6M at December 31, 2024.

Outlook and guidance

  • Cash runway projected into Q4 2027 based on current plans and assumptions.

  • Initial results from frontline silevertinib Phase 2 cohort expected in Q4 2025; final results from recurrent setting anticipated in H1 2026.

  • Exploring partnership opportunities for silevertinib pivotal development and monitoring macroeconomic and regulatory changes.

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Frequently asked questions

Black Diamond Therapeutics, Inc. is a clinical-stage biotechnology company focused on developing precision oncology therapies. The company specializes in "MasterKey" therapies, designed to target a broad range of genetically defined tumors. These therapies aim to overcome resistance to treatment, minimize toxicities associated with targeting healthy cells, and penetrate the blood-brain barrier to address central nervous system (CNS) diseases. The company is headquartered in Cambridge, Massachusetts, and its shares are listed on the NASDAQ.

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