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Boundless Bio (BOLD) investor relations material

Boundless Bio Q2 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q2 2025 earnings summary5 Aug, 2025

Executive summary

  • Focused on precision oncology targeting oncogene amplified tumors using ecDNA-directed therapeutics (ecDTx) and advancing BBI-355/BBI-825 and BBI-940 programs.

  • Portfolio reprioritization in Q2 2025: discontinued certain clinical trial arms, advanced BBI-355/BBI-825 combination, and selected BBI-940 as a new development candidate.

  • Workforce reduced by one-third in Q2 2025 to streamline operations and extend cash runway.

  • No products approved or revenue generated to date; expects continued losses as development progresses.

  • Cash position of $127 million supports operations into the first half of 2028, covering expected proof-of-concept clinical readouts.

Financial highlights

  • Net loss of $15.7 million for Q2 2025, compared to $17.0 million in Q2 2024; net loss per share was $0.70 for Q2 2025, compared to $0.77 for Q2 2024.

  • R&D expenses decreased to $12.2 million in Q2 2025 from $14.7 million in Q2 2024.

  • G&A expenses rose to $4.8 million in Q2 2025 from $4.6 million in Q2 2024.

  • Cash, cash equivalents, and short-term investments totaled $127.1 million as of June 30, 2025.

  • Net cash used in operating activities was $26.4 million for the first half of 2025, down from $32.0 million year-over-year.

Outlook and guidance

  • Existing cash and investments expected to fund operations into the first half of 2028, based on current plans.

  • Initial proof-of-concept clinical data for BBI-355/BBI-825 combination and BBI-940 anticipated within current cash runway.

  • IND submission for BBI-940 anticipated in the first half of 2026.

  • Substantial additional funding will be required for long-term development and commercialization.

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Frequently asked questions

Boundless Bio Inc., trading under the NASDAQ symbol BOLD, is a clinical-stage oncology company focused on developing novel cancer treatments. The company leverages its proprietary Spyglass platform to target extrachromosomal DNA (ecDNA), which plays a significant role in oncogene amplification in over 14% of cancer patients. By identifying and inhibiting targets essential for ecDNA functionality, Boundless Bio aims to develop ecDNA-directed therapeutic candidates (ecDTx) designed to selectively eliminate cancer cells containing ecDNA without harming healthy cells. The company is headquartered in San Diego, California, and its shares are listed on the NASDAQ.

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