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Brii Biosciences (2137) investor relations material
Brii Biosciences H1 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H1 2025 earnings summary21 Aug, 2025
Executive summary
Advanced core HBV functional cure program with three fully enrolled Phase II-B studies (ENSURE, ENRICH, ENHANCE), targeting viral suppression, immune restoration, and optimal combination regimens for chronic HBV treatment.
Out-licensed soralimixin (BRII-693) to Joincare Group for Greater China, focusing resources on HBV and seeking global partners for non-core assets.
Maintained a strong cash position, supporting late-stage development and early discovery pipeline through 2028.
Strategic partnerships and licensing agreements are expanding the pipeline and addressing antimicrobial resistance.
Repurchased 12,723,500 shares for HK$18.2 million, reflecting confidence in business outlook.
Financial highlights
Cash and cash equivalents as of June 30, 2025, were RMB2,075.3 million, down 14% from year-end 2024, supporting operations through 2028.
Other income for H1 2025 was RMB28.1 million, down 60.4% year-over-year, mainly due to lower interest income and reduced government grants.
R&D expenses declined 7.3% year-over-year to RMB117.0 million, reflecting lower third-party and employee costs.
Administrative expenses fell 26% year-over-year to RMB58.2 million, driven by organizational optimization and cost control.
Loss for the period narrowed 47.5% year-over-year to RMB148.8 million, primarily due to reduced net losses from fair value changes in equity investments and lower operating expenses.
Outlook and guidance
24-week follow-up data from ENSURE Cohort 4 expected in H2 2025; end-of-treatment data from ENRICH and ENHANCE studies anticipated in H1 2026.
Unutilized IPO proceeds expected to be fully deployed by end of 2027, mainly for HBV, HIV, and MDR/XDR programs.
Focus remains on advancing HBV cure regimens to registrational studies and expanding early discovery pipeline.
Ongoing regulatory discussions for phase III trial design, with focus on biomarker-driven patient enrichment and combination regimens.
Company remains committed to expanding patient access in China.
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Next Brii Biosciences earnings date
H2 202520 Mar, 2026
Next Brii Biosciences earnings date
H2 202520 Mar, 2026
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Frequently asked questions
Brii Biosciences Limited is a biotechnology company focused on developing therapies for infectious diseases and central nervous system disorders. The company specializes in innovative treatments for conditions such as hepatitis B, HIV, and drug-resistant bacterial infections. It leverages partnerships with global research institutions and biopharmaceutical firms to advance its pipeline through clinical development and regulatory approval. The company is headquartered in Beijing, China, and its shares are listed on the Hong Kong Stock Exchange (HKEX).
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