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C4 Therapeutics
C4 Therapeutics (CCCC) investor relations material
C4 Therapeutics TD Cowen 46th Annual Health Care Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.TD Cowen 46th Annual Health Care Conference summary3 Mar, 2026
Strategic vision and pipeline overview
Focus on targeted protein degradation with a validated clinical oncology portfolio and a sustainable pipeline vision through 2028, including cemsidomide as a lead asset.
Discovery strategy expanded to inflammation, neuroinflammation, and neurodegeneration, targeting undruggable proteins in validated pathways.
Financial runway secured through 2028, supporting key milestones and multiple INDs from the discovery portfolio.
Active collaborations with Roche, Merck KGaA, and Biogen, with productive progress in autoimmune and oncology programs.
Clinical development and trial updates
MOMENTUM phase II study for cemsidomide has begun enrollment, with global site expansion and a 12-month enrollment target.
Phase Ib combination study with elranatamab to start next quarter, aiming to optimize dosing and inform phase III design.
Decision on EGFR L858R degrader (CFT8919) program expected based on ongoing phase I data in China.
Early read on MOMENTUM response rates and combination data expected in the second half of the year; registrational dataset anticipated in 2028.
Cemsidomide profile and differentiation
Cemsidomide demonstrates a best-in-class efficacy and safety profile among IKZF1/3 degraders, with robust activity in late-line, heavily pretreated myeloma patients.
No dose discontinuations due to toxicity and low rates of dose reductions compared to competitors, supporting sustained dosing.
14-day on/14-day off dosing cycle facilitates combination with other therapies and patient tolerability.
Differentiated from CELMoDs by a more favorable balance of efficacy and safety, and a broader therapeutic window.
Cemsidomide's safety profile for combo dosing
C4's unique INN discovery platform advantages
MOMENTUM AA path and MRD-negative CR role
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Next C4 Therapeutics earnings date
Barclays 28th Annual Global Healthcare Conference10 Mar, 2026
C4 Therapeutics
Next C4 Therapeutics earnings date
Barclays 28th Annual Global Healthcare Conference10 Mar, 2026
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Frequently asked questions
C4 Therapeutics Inc. is a clinical-stage biopharmaceutical company focused on targeted protein degradation to develop novel therapies. The company is active in the development of small-molecule medicines designed to selectively target and degrade disease-causing proteins. C4 Therapeutics is leveraging its proprietary technology platforms to advance a pipeline of drug candidates aimed at treating a range of diseases, such as cancer, neurodegenerative conditions, infectious diseases, and autoimmune disorders. The company is headquartered in Watertown, Massachusetts, and its shares are listed on the Nasdaq under the symbol CCCC.
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