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Cadrenal Therapeutics (CVKD) investor relations material
Cadrenal Therapeutics Lytham Partners Fall 2025 Investor Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Company overview and market focus
Focuses on developing novel anticoagulant drugs targeting high-risk and orphan indications within the $38B global oral anticoagulation market, specifically a $2B U.S. segment.
Avoids markets dominated by direct oral anticoagulants, instead addressing end-stage kidney disease, left ventricular assist devices, and mechanical heart valves.
Lead products are tecarfarin, a next-generation vitamin K antagonist, and frunexian, an IV Factor XIa inhibitor for acute care.
Tecarfarin program updates
Tecarfarin is not metabolized by the hepatic cytochrome P450 system, offering more predictable drug levels and fewer drug-drug interactions.
Holds orphan drug and fast track designations for ESKD, AFib, and LVADs, with seven years of exclusivity post-approval.
Phase II/III ready, with drug product manufactured and a phase II study in dialysis patients planned for early 2026.
EmbraceAC study showed tecarfarin matched or outperformed intensively managed warfarin, especially in patients with abnormal metabolism or drug interactions.
Demonstrated stable drug levels in severe kidney disease, unlike warfarin, supporting its use in high-risk populations.
Frunexian acquisition and acute care focus
Frunexian is a fast-on, fast-off IV Factor XIa inhibitor, uniquely positioned for acute care applications such as complex cardiac surgery.
Only Factor XIa inhibitor in development for acute care, with two completed phase I studies.
2026 goals include formulation optimization and advancing towards clinical trials for complex cardiac surgery.
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