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CareDx (CDNA) investor relations material

CareDx Wells Fargo 20th Annual Healthcare Conference 2025 summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Wells Fargo 20th Annual Healthcare Conference 2025 summary5 Sep, 2025

Strategic opportunities and market outlook

  • Early-stage adoption in organ transplant molecular monitoring presents significant growth potential, with molecular testing becoming a standard of care and continued market penetration expected.

  • The company is recognized as an innovator, with a 25-year mission focused on improving patient outcomes in transplantation.

  • Solutions-based selling and a broad portfolio, including software, IVD kits, and molecular monitoring, drive adoption and operational efficiency at transplant centers.

  • Digital solutions and SaaS transformation are key differentiators, supporting two-thirds of U.S. transplant centers and enhancing administrative efficiency.

  • Ongoing investments in commercial teams and technology infrastructure aim to accelerate growth and market reach.

Operational performance and growth drivers

  • Q2 saw strong test volume growth, with kidney testing up nearly 20% and 60 centers adopting surveillance protocols.

  • Surveillance testing adoption is expanding, with over 200 kidney transplant programs in the U.S. and significant room for further protocol implementation.

  • Epic system integration is expected to streamline operations, targeting 10% of volume by year-end and aiming for 50% by next year, despite administrative hurdles.

  • Revenue cycle management overhaul has improved workflows, reduced zero pays, and is projected to increase ASP to $1,400 in the first half of 2025.

  • Digital and patient solutions segment, about 15% of revenue, has grown at a 20–30% CAGR, with bundled solutions driving higher test utilization and revenue.

Policy, payer coverage, and clinical evidence

  • Recent policy changes affirmed coverage for kidney surveillance testing, a major advocacy win, though draft LCDs propose frequency caps and single-test reimbursement per service date.

  • The company submitted detailed feedback advocating for clinician-driven testing frequency and dual-test coverage for heart transplants.

  • The KOR study demonstrated surveillance testing detects rejection up to three months earlier than clinical symptoms, supporting higher test frequency and payer adoption.

  • Expansion of in-network commercial payer contracts, aided by new CPT codes, is expected to improve payment speed, predictability, and utilization.

  • High clinical evidence publication rate supports medical necessity and drives broader payer acceptance.

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Frequently asked questions

CareDx, Inc. discovers, develops, and commercializes diagnostic solutions for transplant patients and caregivers worldwide. It offers UNITY HEART, a precision medicine platform to diagnose the degree of cardiac allograft rejection without the need for a confirmatory endomyocardial biopsy; and UNITY OV, an automated whole blood donor screening system to detect donor-derived cell-free DNA prior to solid organ transplantation and non-invasive as well as categorical monitoring of allograft injury. The company also provides AlloMap heart transplant test that measure mRNA transcripts from 22 genes expressed in immune cells and fibroblasts for personalized patient management; and AlloSure kidney transplant test to measure the amount of a donor specific DNA in a recipient’s bloodstream.

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