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Caris Life Sciences
Caris Life Sciences (CAI) investor relations material
Caris Life Sciences Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary26 Feb, 2026
Executive summary
Achieved record-breaking Q4 and full-year 2025 results, with Q4 revenue up 125% to $293 million and full-year revenue up 97% to $812 million, marking the first year-end as a public company after June IPO.
Molecular profiling services drove growth, with volumes up 22% to 199,300 cases and revenue up 120% to $766.7 million.
Positive GAAP net income of $82 million and adjusted EBITDA of $106 million in Q4; full-year adjusted EBITDA reached $138 million.
Surpassed 1,016,000 genomic profiles in dataset and announced major partnerships, including Genentech and Everlywell.
Cash on hand exceeded $800 million at year-end, providing strong liquidity and strategic flexibility.
Financial highlights
Q4 2025 revenue: $293 million (+125% year-over-year); full-year 2025 revenue: $812 million (+97%).
Gross margin improved to 75% in Q4 and 66% for the full year.
Adjusted EBITDA for 2025 was $138 million; free cash flow for the year was $67 million.
Pharma R&D services revenue declined in 2025 but is expected to rebound in 2026.
ASP for tissue reached $3,876 in 2025, with blood ASP at $2,500.
Outlook and guidance
2026 revenue guidance: $1.0–$1.02 billion (+23–26% year-over-year).
Molecular profiling revenue projected to grow 21–22% in 2026; therapy selection volume expected to grow ~20%.
Pharma/research revenue expected at $75–$85 million in 2026.
GAAP operating expenses projected at $590–$595 million (+19–20%), mainly for commercial and R&D expansion.
Positive adjusted EBITDA and free cash flow expected to be maintained in 2026.
Quantify 2025 molecular profiling over collections
Drivers of improved molecular profiling reimbursement
Reason for 2025 pharma & research revenue decline
Caris Detect: specificity for asymptomatic vs high-risk?
Sales force expansion: expected volume impact in 2026?
Update on MI Cancer Seek and MI Clarity launch plans?
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Next Caris Life Sciences earnings date
Q1 20266 May, 2026
Caris Life Sciences
Next Caris Life Sciences earnings date
Q1 20266 May, 2026
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