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Cassava Sciences (SAVA) investor relations material
Cassava Sciences H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.H.C. Wainwright 27th Annual Global Investment Conference summary8 Sep, 2025
Leadership and strategic direction
New executive leadership was established in July 2024 following regulatory investigations and a management transition.
The company resolved an SEC investigation with a settlement, closing a challenging chapter.
Focus shifted to leveraging a strong board and scientific team, including recent key hires with deep expertise in neuroscience and drug development.
The board chair and new executives bring significant experience in drug approvals and clinical trial management.
Pipeline and research focus
After phase 3 failure in Alzheimer's, attention turned to TSC-related epilepsy, supported by promising preclinical data.
Simufilam showed significant seizure reduction in mouse models, with up to 60% reduction and some mice becoming seizure-free.
The drug demonstrated a strong safety profile in over 1,200 patients with no drug-related serious adverse events.
Intellectual property for simufilam is secured through 2040, with broad patent coverage.
Clinical and commercial plans
A phase 2A proof-of-concept trial in TSC-related epilepsy is planned for the first half of 2026.
The company is preparing an IND submission, with approval expected by year-end.
TSC represents a significant unmet need, with 50,000 US patients and over 60% inadequately controlled by current therapies.
The company owns the drug outright for this indication, with licensing and royalty agreements in place with Yale.
Timeline for AD trial failure manuscript publication
Elaborate on simufilam's root cause MOA for TSC
Funding strategy post-Q2 2027 cash runway
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Next Cassava Sciences earnings date
Q3 20256 Nov, 2025
Next Cassava Sciences earnings date
Q3 20256 Nov, 2025
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Frequently asked questions
Cassava Sciences, Inc. is a clinical-stage biotechnology company focused on developing novel treatments for neurodegenerative diseases, with a primary focus on Alzheimer’s disease. The company’s leading drug candidate, simufilam, is an oral small molecule in 3 clinical trials aimed at treating Alzheimer’s by targeting an altered form of a brain protein known as filamin A. Cassava Sciences is also developing SavaDx, an investigational diagnostic tool designed to detect Alzheimer's disease through a blood test. The company is headquartered in Austin, Texas, and its shares are listed on the NASDAQ.
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