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Celldex Therapeutics (CLDX) investor relations material
Celldex Therapeutics Evercore ISI 8th Annual HealthCONx Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Evercore ISI 8th Annual HealthCONx Conference summary2 Dec, 2025
Company and pipeline overview
Entered late-stage development with phase III CSU program; phase III CIndU to start by end of month.
Phase II studies in prurigo nodularis and atopic dermatitis expected to read out in 2026.
CDX-622, a bispecific targeting SCF and TSLP, is in healthy volunteer studies; multiple ascending dose (MAD) data expected Q3 2026.
Subcutaneous dosing and proof-of-mechanism asthma study planned for 2026.
Scientific and clinical insights
CDX-622 targets soluble SCF-248, aiming to inhibit mast cells while minimizing KIT-related side effects.
Maximum 50% tryptase reduction observed in SAD; further reduction possible with MAD.
Skin punch biopsies and preclinical models will clarify tissue-specific mast cell inhibition.
TSLP biomarker effects to be studied in an asthma biomarker trial.
Commercial and market strategy
Barzal expected to launch behind OMA but could target both antihistamine-refractory and biologic-experienced populations.
Pricing anticipated to exceed $40,000/year, potentially seeking a premium over recent analogs.
U.S. OMA patient base estimated at 80,000–112,000, with broader reach possible.
Patient selection in atopic dermatitis study is broad; all prior therapies allowed after washout.
Clinical significance of 50% tryptase reduction?
Justify Barzal's premium pricing to payers
How does 622 validate the SCF-targeted platform?
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Next Celldex Therapeutics earnings date
Q4 202523 Feb, 2026
Next Celldex Therapeutics earnings date
Q4 202523 Feb, 2026
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Frequently asked questions
Celldex Therapeutics, Inc. is a biopharmaceutical company specializing in the development of therapeutic monoclonal and bispecific antibodies. These antibodies are designed to treat a range of serious conditions, including inflammatory, allergic, and autoimmune diseases. The company's lead program focuses on developing barzolvolimab, a monoclonal antibody targeting KIT, a key receptor tyrosine kinase involved in mast cell function, which is crucial in the onset and progression of various severe diseases. Celldex Therapeutics is headquartered in Hampton, New Jersey, and its shares are listed on the NASDAQ.
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