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Celldex Therapeutics
Celldex Therapeutics (CLDX) investor relations material
Celldex Therapeutics Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary25 Feb, 2026
Executive summary
Completed enrollment in two global Phase 3 chronic spontaneous urticaria (CSU) studies six months ahead of schedule; topline data expected Q4 2026 and BLA submission planned for 2027.
Phase 3 cold urticaria and symptomatic dermographism study actively accruing; Phase 2 prurigo nodularis and atopic dermatitis studies completed enrollment with data expected in 2026.
Initiated Phase 1 proof of mechanism study for CDX-622 in asthma; multiple key clinical readouts anticipated in 2026.
Financial highlights
Cash, cash equivalents, and marketable securities were $518.6M as of December 31, 2025, down from $583.2M at September 30, 2025, due to increased clinical and manufacturing expenses.
Total revenue was $0.1M in Q4 2025 and $1.5M for the year, compared to $1.2M and $7.0M for the same periods in 2024, reflecting lower R&D service revenue.
R&D expenses rose to $75.3M in Q4 2025 and $245.1M for the year, up from $46.9M and $163.6M in 2024, driven by barzolvolimab trials and increased headcount.
G&A expenses increased to $11.9M in Q4 2025 and $43.8M for the year, up from $10.3M and $38.5M in 2024, due to higher headcount and commercial planning.
Net loss was $81.3M ($1.22/share) in Q4 2025 and $258.8M ($3.90/share) for the year, compared to $47.1M ($0.71/share) and $157.9M ($2.45/share) in 2024.
Outlook and guidance
Cash position is expected to fund operations through 2027.
Anticipates multiple clinical data readouts in 2026, including Phase 3 CSU, Phase 2 prurigo nodularis, and atopic dermatitis.
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Next Celldex Therapeutics earnings date
TD Cowen 46th Annual Health Care Conference4 Mar, 2026
Celldex Therapeutics
Next Celldex Therapeutics earnings date
TD Cowen 46th Annual Health Care Conference4 Mar, 2026
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Frequently asked questions
Celldex Therapeutics, Inc. is a biopharmaceutical company specializing in the development of therapeutic monoclonal and bispecific antibodies. These antibodies are designed to treat a range of serious conditions, including inflammatory, allergic, and autoimmune diseases. The company's lead program focuses on developing barzolvolimab, a monoclonal antibody targeting KIT, a key receptor tyrosine kinase involved in mast cell function, which is crucial in the onset and progression of various severe diseases. Celldex Therapeutics is headquartered in Hampton, New Jersey, and its shares are listed on the NASDAQ.
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