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Century Therapeutics
Century Therapeutics (IPSC) investor relations material
Century Therapeutics TD Cowen 46th Annual Health Care Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.TD Cowen 46th Annual Health Care Conference summary4 Mar, 2026
Strategic priorities and program focus
Advancing two main programs: CNTY-813 for Type 1 Diabetes and CNTY-308 for B-cell-mediated autoimmune diseases, both featuring advanced Allo-Evasion 5.0 technology.
IND submission for CNTY-813 targeted for late 2024, with clinical entry and initial data generation as key 12–24 month goals.
CNTY-308 aims to enter the clinic in 2024, leveraging iPSC-derived T cells with immune evasion to potentially reduce or eliminate lymphodepletion.
Long-term vision includes expanding iPSC-derived therapies to additional diseases and leveraging internal capabilities in developmental biology and manufacturing.
Technology platform and differentiation
iPSC-derived cells offer unlimited scalability and the ability to generate any adult cell type, supporting broad therapeutic applications.
Allo-Evasion 5.0 removes HLA Class I/II, adds a universal NK inhibitory ligand (CD300a TASR), and expresses an IgG-degrading protease for comprehensive immune protection.
Preclinical data show superior protection against NK and IgG-mediated rejection compared to other technologies.
Allo-Evasion 5.0 is positioned as best-in-class for immune evasion, with broad applicability across cell types.
CNTY-813 (Type 1 Diabetes) program details
Addresses significant unmet need: 10 million global T1D patients, many experiencing severe hypoglycemic events and long-term complications despite insulin therapy.
Cadaveric islet transplant data support the approach but are limited by need for chronic immunosuppression.
Preclinical studies confirm iPSC-derived beta islet cells match gene expression and function of native islets, restoring normoglycemia in diabetic animal models.
IND-enabling studies are progressing, with positive FDA feedback and focus on tumorigenicity and toxicity studies.
Early clinical trials will assess safety, engraftment, insulin independence, and reduction of immunosuppression, with pivotal data expected by 2027 and potential commercialization in early 2030s.
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Next Century Therapeutics earnings date
Leerink Global Healthcare Conference 202610 Mar, 2026
Century Therapeutics
Next Century Therapeutics earnings date
Leerink Global Healthcare Conference 202610 Mar, 2026
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Frequently asked questions
Century Therapeutics Inc. is a biotechnology company focused on developing innovative cell therapy products. The company specializes in the creation of allogeneic cell therapies derived from induced pluripotent stem cells (iPSCs). These therapies are designed to treat a range of conditions, including solid tumors and hematological malignancies. Century Therapeutics' leading product candidates include therapies targeting specific cancer markers, such as CD19 and Nectin-4, and are developed through advanced gene editing and cellular engineering technologies. The company is headquartered in Philadelphia, Pennsylvania, and its shares are listed on the NASDAQ.
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