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Century Therapeutics (IPSC) investor relations material

Century Therapeutics Chardan’s 9th Annual Genetic Medicines Conference summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Chardan’s 9th Annual Genetic Medicines Conference summary21 Oct, 2025

Strategic focus and pipeline evolution

  • Accelerating core programs, including CNTY-101 (NK cell-based, CD19 CAR) and CNTY-308 (iPSC-derived alpha-beta T cells), with clinical and preclinical trials in autoimmune and B-cell-mediated diseases.

  • CNTY-308 is in IND-enabling studies, targeting clinical entry mid-next year, representing a first in generating autologous-like T cells from iPSC.

  • A new non-immune cell program is advancing rapidly, positioned in a non-competitive space.

  • Restructuring has focused resources on key assets and extended cash runway through 2027.

Technological advancements and alloevasion platform

  • Industry-leading alloevasion technology has evolved from 1.0 (in CNTY-101) to 5.0 (in CNTY-308 and preclinical programs), providing robust immune evasion.

  • Alloevasion 5.0 includes CD300A “taser” for universal NK cell defense and an IgG-degrading protease for humoral protection.

  • These edits enable off-the-shelf cell therapies with enhanced persistence and reduced need for lymphodepletion.

  • Proprietary differentiation process yields tunable mixtures of CD4 and CD8 T cells, matching autologous CAR T efficacy.

Clinical and preclinical data highlights

  • iPSC-derived T cells show comparable efficacy, proliferation, and persistence to autologous CAR T cells in preclinical models, including durable tumor control and re-challenge response.

  • NK cell-based CNTY-101 is in two clinical trials (Calypso and Caramel) for autoimmune diseases, with flexible dosing and strong safety profile.

  • Deep, sustained B cell depletion and tissue penetration observed in B cell malignancy and autoimmune trials, with alloevasion enabling persistence without lymphodepletion.

  • Data readouts from Calypso are expected this year, with aggregation of data from both trials as possible.

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Q3 20257 Nov, 2025
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Frequently asked questions

Century Therapeutics Inc. is a biotechnology company focused on developing innovative cell therapy products. The company specializes in the creation of allogeneic cell therapies derived from induced pluripotent stem cells (iPSCs). These therapies are designed to treat a range of conditions, including solid tumors and hematological malignancies. Century Therapeutics' leading product candidates include therapies targeting specific cancer markers, such as CD19 and Nectin-4, and are developed through advanced gene editing and cellular engineering technologies. The company is headquartered in Philadelphia, Pennsylvania, and its shares are listed on the NASDAQ.

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