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Charles River Laboratories
Charles River Laboratories (CRL) investor relations material
Charles River Laboratories Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary18 Feb, 2026
Executive summary
2025 results reached the upper end of revenue and non-GAAP EPS guidance, with stabilization in biopharma demand and strategic progress in portfolio and innovation initiatives.
CEO Jim Foster announced retirement, with Birgit Girshick named as successor, and new CFO and CLO appointments to strengthen leadership.
Fourth-quarter revenue was $994.2 million, down 0.8% year-over-year; full-year revenue was $4.02 billion, down 0.9% year-over-year.
Non-cash impairments and goodwill charges significantly impacted GAAP results, especially in Biologics Solutions and Cell Solutions.
Management highlighted improved DSA net bookings in Q4 and ongoing strategic initiatives for future growth.
Financial highlights
FY 2025 revenue was $4,015.4M, down 0.9% year-over-year; organic revenue declined 1.6%.
4Q25 revenue was $994.2M, down 0.8% year-over-year; organic revenue declined 2.6%.
FY 2025 non-GAAP operating margin was 19.8%, down 10 bps; 4Q25 non-GAAP operating margin was 18.1%, down 180 bps.
FY 2025 non-GAAP EPS was $10.28, nearly flat year-over-year; 4Q25 non-GAAP EPS was $2.66, down 10.2%.
Free cash flow for 2025 was $518.5M; 2026 guidance is $375–$400M.
Outlook and guidance
2026 reported revenue growth expected to be at least flat to +1.5%; organic revenue growth expected between (1.0)% and flat.
2026 non-GAAP EPS guidance is $10.70–$11.20, representing 4–9% year-over-year growth, driven by cost savings, acquisitions, and a lower tax rate.
Non-GAAP operating margin expected to improve by 20–50 bps, driven by the K.F. acquisition.
1Q26 non-GAAP EPS expected to decline high-teens year-over-year due to timing of NHP shipments, CEO transition costs, and higher DSA costs.
Guidance does not include the impact of planned divestitures representing about 7% of 2025 revenue.
Impact of Biologics/Cell Solutions impairments?
DSA Q4 revenue vs. booking trends reconciliation
Rationale for 7% revenue divestitures in 2026?
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Next Charles River Laboratories earnings date
Q1 20266 May, 2026
Charles River Laboratories
Next Charles River Laboratories earnings date
Q1 20266 May, 2026
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Frequently asked questions
Charles River Laboratories International, Inc. is a concract research organization providing drug discovery, non-clinical development and safety testing services in the United States, Europe, Canada and the Asia Pacific regions. The Company provides research models and related services to support clients from target identification through non-clinical development. The Company operates through three segments: Research Models and Services (RMS), Discovery and Safety Assessment (DSA), and Manufacturing Support.
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