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Edge20 Feb 2026
Dollar General: The Rural Retailer Playbook
How Dollar General built a small-box empire across rural America, scaling value and convenience into one of retail's most durable business models.
Climb Bio
Climb Bio (CLYM) investor relations material
Climb Bio Corporate presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Corporate presentation summary5 Mar, 2026
Mission and strategy
Focused on developing disease-modifying monoclonal antibody (mAb) therapies for immune-mediated diseases, especially those impacting kidney health.
Leveraging clinically validated B cell targets and proven mAb modalities for indications with clear endpoints and regulatory pathways.
Targeting expansive commercial opportunities in diseases with high unmet need, including primary membranous nephropathy (PMN), immune thrombocytopenia (ITP), systemic lupus erythematosus (SLE), and IgA nephropathy (IgAN).
Anticipating multiple clinical readouts in 2026 across both lead programs.
Cash runway extends into 2028, supporting advancement through key milestones.
Clinical pipeline and development
Five clinical studies underway, with initial data expected from all ongoing trials in 2026.
Budoprutug (anti-CD19 mAb) in development for PMN, ITP, and SLE, with both IV and SC formulations.
CLYM116 (anti-APRIL mAb) in development for IgAN, with Phase 1 data in healthy volunteers expected mid-2026.
Budoprutug SC Phase 1 trial dosing completed; data anticipated H1 2026.
Global and China SLE Phase 1b trials for budoprutug enrolling, with initial data expected H2 2026.
Budoprutug: clinical data and differentiation
Demonstrated rapid, deep, and durable B cell depletion in PMN, with 100% serologic remission and all patients achieving clinical remission by Week 48 in Phase 1b.
Well-tolerated safety profile in Phase 1b PMN trial, with no deaths, no dose-limiting toxicities, and no discontinuations due to adverse events.
Competitive profile in PMN compared to other therapies, with high rates of serologic and clinical remission.
SC formulation offers potential for at-home administration and broader patient reach.
Partial view of Summaries dataset, powered by Quartr API
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Next Climb Bio earnings date
Leerink Global Healthcare Conference 20269 Mar, 2026
Climb Bio
Next Climb Bio earnings date
Leerink Global Healthcare Conference 20269 Mar, 2026
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Eliem Therapeutics, Inc. is a biotechnology company focused on developing therapies for neuronal excitability disorders, which are associated with conditions like chronic pain, epilepsy, depression, and anxiety. The company’s approach involves advancing clinical-stage compounds that target neurological diseases, aiming to address significant unmet medical needs. Eliem Therapeutics is headquartered in Wilmington, Delaware, and its shares are listed on the NASDAQ.
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