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Climb Bio
Climb Bio (CLYM) investor relations material
Climb Bio Investor Presentation summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Investor Presentation summary8 Jan, 2026
Mission and strategy
Focused on developing disease-modifying monoclonal antibody (mAb) therapeutics for immune-mediated diseases, especially those impacting kidney health, with significant commercial potential.
Leveraging clinically validated B cell targets and proven mAb modalities for indications with established regulatory pathways.
Aims to deliver transformative medicines for patients with high unmet needs in B cell-mediated and autoimmune diseases.
Pipeline and clinical development
Five clinical studies underway, with initial data readouts anticipated from all ongoing trials in 2026.
Budoprutug (anti-CD19 mAb) in development for primary membranous nephropathy (PMN), immune thrombocytopenia (ITP), and systemic lupus erythematosus (SLE); CLYM116 (anti-APRIL mAb) in development for IgA nephropathy (IgAN).
Budoprutug offers both IV and subcutaneous (SC) formulations, with SC Phase 1 trial in healthy volunteers ongoing.
CLYM116 Phase 1 trial in healthy volunteers is ongoing, with initial data expected mid-2026.
Clinical results and differentiation
Budoprutug demonstrated rapid, deep, and durable B cell depletion and high rates of serologic and clinical remission in PMN Phase 1b study.
All patients in the primary analysis set achieved complete or partial clinical remission by Week 48, with long-term control of proteinuria observed.
Budoprutug was generally well tolerated, with no dose-limiting toxicities or discontinuations due to adverse events.
CLYM116 preclinical and NHP data show deep and durable IgA suppression, long half-life, and favorable safety profile.
CLYM116: Sweeper MoA benefits vs. competitors
China market strategy for pipeline assets
Budoprutug: PrisMN data to accelerate Phase 3
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Next Climb Bio earnings date
Q4 202527 Mar, 2026
Climb Bio
Next Climb Bio earnings date
Q4 202527 Mar, 2026
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