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Compugen
Compugen (CGEN) investor relations material
Compugen Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary2 Mar, 2026
Executive summary
Extended cash runway into 2029 through a $65M upfront non-dilutive transaction with AstraZeneca, plus $25M at BLA acceptance and up to $195M in total milestones.
Leadership transition with Dr. Eran Ophir appointed President and CEO in September 2025 and Dr. Anat Cohen-Dayag as Executive Chair.
Advanced clinical programs for COM-701 and GS-0321, with new trials initiated and global site expansion.
Presented clinical updates for COM701 and GS-0321 at major oncology conferences.
AstraZeneca reported promising Phase 2 rilvegostomig data and is conducting 10+ ongoing Phase 3 trials.
Financial highlights
Cash, cash equivalents, and investments totaled $145.6M as of December 31, 2025, including a $65M upfront payment from AstraZeneca.
Reported Q4 2025 revenues of $67.3M and full-year 2025 revenues of $72.8M, up from $1.5M and $27.9M in 2024, driven by AstraZeneca and Gilead payments.
Net profit for Q4 2025 was $56.8M ($0.60/share) and for the year $35.3M ($0.38/share), compared to net losses in 2024.
R&D expenses for 2025 were $22.8M, down from $24.8M in 2024; G&A expenses were $8.9M, down from $9.4M.
No debt as of year-end 2025.
Outlook and guidance
Cash runway expected to fund operations into 2029, supporting ongoing and new clinical trials.
Interim analysis for the MAIA-ovarian COM-701 trial expected in Q1 2027.
Further Phase 1/2 clinical data for rilvegostomig anticipated in 2026.
Continued investment in early-stage pipeline and computational discovery platform.
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Next Compugen earnings date
Leerink Global Healthcare Conference 20269 Mar, 2026
Compugen
Next Compugen earnings date
Leerink Global Healthcare Conference 20269 Mar, 2026
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Frequently asked questions
Compugen Ltd. is a clinical-stage therapeutic discovery and development company that focuses on immuno-oncology and autoimmune diseases. The company leverages a predictive computational discovery platform to identify novel drug targets and develop therapeutic products. Its pipeline includes a range of products in clinical trials, such as COM701 and COM902, which target various cancers including non-small cell lung cancer and head and neck squamous cell carcinoma. The company is headquartered in Holon, Israel, and its shares are listed on the NASDAQ.
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