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Crinetics Pharmaceuticals
Crinetics Pharmaceuticals (CRNX) investor relations material
Crinetics Pharmaceuticals Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary26 Feb, 2026
Executive summary
Achieved FDA approval and U.S. launch of PALSONIFY (paltusotine) for acromegaly, generating $5.4M in Q4 2025 net product revenue and over 200 enrollment forms by year-end, with strong early market adoption and leadership in acromegaly treatment.
Advanced late-stage pipeline with phase III studies for Atumelnant in CAH and Cushing's disease, and initiated phase I/II for CRN09682 in SST2-expressing/neuroendocrine tumors.
EMA's CHMP issued a positive opinion for PALSONIFY in Europe, pending EC approval, supporting global regulatory expansion.
Built a fully integrated pharmaceutical company with robust infrastructure and R&D capabilities.
Well-funded with cash runway extending into 2030, supporting ongoing and future strategic initiatives.
Financial highlights
Q4 2025 net revenue was $6.2M, including $5.4M from PALSONIFY and $0.8M from a Japanese licensing agreement; full-year 2025 revenue totaled $7.7M, up from $1.0M in 2024.
R&D expenses for Q4 were $85.1M and $332.1M for the year, up from $66.6M and $240.2M in 2024.
SG&A expenses were $53.7M in Q4 and $191.3M for the year, compared to $28.2M and $99.7M in 2024.
Net loss widened to $122.8M for Q4 2025 and $465.3M for the year, versus $80.6M and $298.4M in 2024.
Cash, cash equivalents, and investments totaled $1.0B at year-end 2025, rising to $1.4B post-January 2026 offering.
Outlook and guidance
2026 GAAP operating expenses expected between $600M–$650M; non-GAAP between $480M–$520M.
Cash runway projected to fund operations and strategic initiatives into 2030, supporting commercialization and pivotal clinical readouts.
Multiple value-creating milestones anticipated, including pivotal clinical trial readouts and further commercialization.
What drives Palsonify commercial scaling?
Atumelnant's path to best-in-class status
Capital allocation for pipeline expansion
Quickstart program evolution over time
ADCS study design rationale vs. alternatives?
9682 platform: oncology expansion strategy?
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Next Crinetics Pharmaceuticals earnings date
TD Cowen 46th Annual Health Care Conference4 Mar, 2026
Crinetics Pharmaceuticals
Next Crinetics Pharmaceuticals earnings date
TD Cowen 46th Annual Health Care Conference4 Mar, 2026
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Frequently asked questions
Crinetics Pharmaceuticals Inc. is a clinical-stage pharmaceutical company that specializes in the development of novel therapeutics targeting peptide hormone receptors. Their focus is on the treatment of rare endocrine disorders and endocrine-related tumors. The company’s leading product candidate is Paltusotine, an oral selective nonpeptide somatostatin receptor type 2 agonist. It is in advanced clinical trials for conditions such as acromegaly, carcinoid syndrome, and nonfunctional neuroendocrine tumors. Additionally, Crinetics Pharmaceuticals is developing other drug candidates for conditions like congenital hyperinsulinism and Cushing's disease. The company is headquartered in San Diego, California, and its shares are listed on the NASDAQ.
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