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Delcath Systems (DCTH) investor relations material
Delcath Systems Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Executive summary
Achieved record annual revenue of $85.2 million in 2025, up over 40% year-over-year, with $20.7 million in Q4 alone.
HEPZATO KIT drove $78.8 million in annual revenue, with CHEMOSAT contributing $6.4 million.
Ended 2025 with 28 active treatment centers and 140% growth in HEPZATO procedure volume compared to 2024, targeting 40 centers by end of 2026.
CHOPIN trial data demonstrated significant clinical benefit for PHP when sequenced with checkpoint inhibitors, with publication imminent.
Commercial strategy focuses on expanding site capacity, changing prescribing patterns, and building referral networks.
Financial highlights
Q4 2025 revenue: $19 million from HEPZATO and $1.7 million from CHEMOSAT; full year: $78.8 million HEPZATO, $6.4 million CHEMOSAT.
Gross margins: 85% in Q4 and 86% for 2025, up from 83% in 2024.
Q4 2025 net loss: $1.9 million (improved from $3.4 million loss in Q4 2024); full year 2025 net income: $2.7 million (vs. $26.4 million loss in 2024).
Adjusted EBITDA for 2025: $25.1 million, up from a $2.5 million loss in 2024.
Ended 2025 with $91 million in cash and investments; $22.5 million operating cash flow for the year.
Outlook and guidance
2026 revenue guidance: at least $100 million, with >20% HEPZATO KIT volume growth and >10% CHEMOSAT growth.
Gross margin guidance for 2026: 84%-87%, with potential to reach 90% in 2027 and beyond.
R&D expenses expected to increase by nearly 90% in 2026; SG&A to rise by nearly 50%.
Anticipates accelerated adoption and utilization driven by new site activations and positive clinical data.
Average selling price for HEPZATO projected at $175,000 per kit, reflecting a 10% discount due to 340B pricing.
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