Delcath Systems
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Delcath Systems (DCTH) investor relations material

Delcath Systems Q4 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q4 2025 earnings summary26 Feb, 2026

Executive summary

  • Achieved record annual revenue of $85.2 million in 2025, up over 40% year-over-year, with $20.7 million in Q4 alone.

  • HEPZATO KIT drove $78.8 million in annual revenue, with CHEMOSAT contributing $6.4 million.

  • Ended 2025 with 28 active treatment centers and 140% growth in HEPZATO procedure volume compared to 2024, targeting 40 centers by end of 2026.

  • CHOPIN trial data demonstrated significant clinical benefit for PHP when sequenced with checkpoint inhibitors, with publication imminent.

  • Commercial strategy focuses on expanding site capacity, changing prescribing patterns, and building referral networks.

Financial highlights

  • Q4 2025 revenue: $19 million from HEPZATO and $1.7 million from CHEMOSAT; full year: $78.8 million HEPZATO, $6.4 million CHEMOSAT.

  • Gross margins: 85% in Q4 and 86% for 2025, up from 83% in 2024.

  • Q4 2025 net loss: $1.9 million (improved from $3.4 million loss in Q4 2024); full year 2025 net income: $2.7 million (vs. $26.4 million loss in 2024).

  • Adjusted EBITDA for 2025: $25.1 million, up from a $2.5 million loss in 2024.

  • Ended 2025 with $91 million in cash and investments; $22.5 million operating cash flow for the year.

Outlook and guidance

  • 2026 revenue guidance: at least $100 million, with >20% HEPZATO KIT volume growth and >10% CHEMOSAT growth.

  • Gross margin guidance for 2026: 84%-87%, with potential to reach 90% in 2027 and beyond.

  • R&D expenses expected to increase by nearly 90% in 2026; SG&A to rise by nearly 50%.

  • Anticipates accelerated adoption and utilization driven by new site activations and positive clinical data.

  • Average selling price for HEPZATO projected at $175,000 per kit, reflecting a 10% discount due to 340B pricing.

What drives the 2026 HEPZATO volume growth forecast
HEPZATO mCRC/mBC trial: market potential
How CHOPIN data changes HEPZATO commercial strategy
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Frequently asked questions

Delcath Systems Inc. is a medical technology company focused on the development and commercialization of innovative therapies for cancers with limited treatment options. The company specializes in targeted drug delivery systems, designed to isolate and deliver high doses of chemotherapy to specific organs or regions while minimizing systemic exposure. The company is headquartered in Wilmington, Delaware, and its shares are listed on the NASDAQ.

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