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Delcath Systems (DCTH) investor relations material

Delcath Systems Study Result summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Study Result summary20 Oct, 2025

CHOPIN trial design and objectives

  • The CHOPIN phase II trial randomized 76 patients with metastatic uveal melanoma to receive either percutaneous hepatic perfusion (PHP) alone or in combination with ipilimumab and nivolumab over nine weeks.

  • The primary endpoint was one-year progression-free survival; secondary endpoints included safety, best overall response rate, overall survival, and hepatic progression-free survival.

  • 76 patients were randomized 1:1 to receive either PHP alone or PHP plus immune checkpoint inhibitors.

Key efficacy results

  • One-year progression-free survival was 54.7% for the combination group versus 15.8% for PHP alone; median overall survival was 23.1 vs. 19.6 months; best overall response rates were 76.3% vs. 39.5%.

  • One-year overall survival was 82.8% for the combination group and 82.2% for PHP alone; two-year overall survival was 49.6% versus 22.1%.

  • All efficacy advantages for the combination were statistically significant.

Safety and tolerability

  • Grade 3 or higher treatment-related adverse events were more frequent in the combination group (81.6% vs. 40.5%) but were generally manageable with standard care.

  • No new safety signals were identified; adverse event profiles were consistent with known effects of PHP and checkpoint inhibitors.

  • The trial did not include additional PHP treatments beyond two cycles or nivolumab maintenance therapy.

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Frequently asked questions

Delcath Systems Inc. is a medical technology company focused on the development and commercialization of innovative therapies for cancers with limited treatment options. The company specializes in targeted drug delivery systems, designed to isolate and deliver high doses of chemotherapy to specific organs or regions while minimizing systemic exposure. The company is headquartered in Wilmington, Delaware, and its shares are listed on the NASDAQ.

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