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Edgewise Therapeutics
Edgewise Therapeutics (EWTX) investor relations material
Edgewise Therapeutics Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary26 Feb, 2026
Executive summary
Advanced late-stage clinical programs in muscular dystrophy and cardiovascular diseases, with multiple pivotal trial readouts expected in 2026 and 2027.
Strong progress in Becker muscular dystrophy (GRAND CANYON), Duchenne (LYNX, FOX), and HCM (CIRRUS-HCM) programs.
Entered 2026 with significant cash reserves and a robust pipeline targeting high unmet medical needs.
Financial highlights
Cash, cash equivalents, and marketable securities totaled $530.1 million as of December 31, 2025.
R&D expenses for Q4 2025 were $43.6 million, up from $37.5 million in Q3 2025, mainly due to increased personnel and clinical development costs.
G&A expenses for Q4 2025 were $12.4 million, up from $9.4 million in Q3 2025, driven by higher personnel and professional fees.
Net loss for Q4 2025 was $50.2 million ($0.47 per share), compared to $40.7 million ($0.39 per share) in Q3 2025.
Outlook and guidance
Top-line data from the pivotal GRAND CANYON trial in Becker expected in Q4 2026, with NDA submission planned for H1 2027.
CIRRUS-HCM 12-week Part D data for EDG-7500 in HCM expected in H1 2026; Phase 3 initiation planned for H2 2026.
Phase 1 data for EDG-15400 and plans for heart failure studies expected in H1 2026; Phase 2 in HFpEF to start in H2 2026.
What are key steps for sevasemten NDA post-data?
Explain the shift in sevasemten R&D spend.
How will Part D data refine EDG-7500 Phase 3 strategy?
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Next Edgewise Therapeutics earnings date
Q1 20267 May, 2026
Edgewise Therapeutics
Next Edgewise Therapeutics earnings date
Q1 20267 May, 2026
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Frequently asked questions
Edgewise Therapeutics Inc. (EWTX) is a clinical-stage biopharmaceutical company dedicated to the discovery, development, and commercialization of innovative treatments for severe, rare muscle disorders, addressing significant unmet medical needs. Utilizing its proprietary drug discovery platform, Edgewise focuses on targeting the muscle as an organ, combining expertise in muscle biology and small molecule engineering. This approach allows the identification of precision medicines regulating key proteins in muscle tissue. Edgewise Therapeutics is headquartered in Boulder, Colorado, and its shares are listed on the Nasdaq.
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