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Edge14 Nov 2025
Ball: The King of Cans
From a 19th-century glass-jar legacy to a global plant network, Ball is now a pure-play aluminum can partner to the world's biggest beverage brands.
enGene Holdings (ENGN) investor relations material
enGene Holdings Jefferies London Healthcare Conference 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Jefferies London Healthcare Conference 2025 summary18 Nov, 2025
Key product and technology highlights
Lead asset detalimogene voraplasmid is a non-viral gene therapy for non-muscle invasive bladder cancer (NMIBC).
Demonstrates strong efficacy, tolerability, and ease of use, targeting community urologists.
Non-viral approach allows for larger genetic payload, redosing, and lower manufacturing costs.
Product consists of two RIG-I agonists and IL-12, stimulating both innate and adaptive immunity.
Manufacturing is scalable, cost-effective, and does not require special handling or storage.
Market and patient landscape
NMIBC affects about 730,000 people in the US, with 65,000 new cases annually.
NMIBC is the sixth most common cancer in the US, with high treatment costs.
Current standard BCG therapy faces chronic shortages and challenging administration.
Community urologists manage most NMIBC cases, with unique logistical and economic pressures.
Buy-and-bill is a growing revenue model for urologists, expected to reach 15-20% of revenue by 2025.
Clinical development and data
Pivotal LEGEND trial fully enrolled 125 BCG-unresponsive NMIBC patients, largest cohort in this indication.
Recent data update: six-month complete response (CR) rate of 62%, with strong tolerability (mostly grade 1/2 AEs).
Protocol amendments improved efficacy from 41% to 62% at six months.
Dose interruptions and discontinuations are low (1.6% and 0.8%, respectively).
Efficacy and tolerability compare favorably to approved and in-development agents.
How does buy-and-bill strategy impact market share?
Detail manufacturing advantages over competitors
Beyond NMIBC, what's next for STDX platform?
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Next enGene Holdings earnings date
Q4 202519 Dec, 2025
Next enGene Holdings earnings date
Q4 202519 Dec, 2025
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Frequently asked questions
enGene Holdings Inc. operates through its subsidiary, enGene, Inc., as a clinical-stage biotechnology company focused on developing genetic medicines. The company specializes in the delivery of therapeutics to mucosal tissues and other organs using non-viral methods. Its primary product candidate is EG-70 (detalimogene voraplasmid), a non-viral immunotherapy aimed at treating non-muscle invasive bladder cancer in patients unresponsive to traditional treatments. The company is headquartered in Montreal, Quebec, Canada, and its shares are listed on the NASDAQ.
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