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Enliven Therapeutics
Enliven Therapeutics (ELVN) investor relations material
Enliven Therapeutics Q4 2025 earnings summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Q4 2025 earnings summary3 Mar, 2026
Executive summary
Reported positive initial Phase 1b data for ELVN-001 in chronic myeloid leukemia (CML), showing strong efficacy in heavily pretreated patients.
Initiation of Phase 3 ENABLE-2 pivotal trial for ELVN-001 expected in the second half of 2026, with key data readouts and regulatory milestones anticipated throughout 2026.
Leadership transition with Rick Fair appointed CEO in December 2025 and Scott Garland joining the Board in January 2026, aligning governance for late-stage development and commercialization.
Financial highlights
Cash, cash equivalents, and marketable securities totaled $462.6 million as of December 31, 2025, providing runway into the first half of 2029.
R&D expenses were $21.2 million for Q4 2025 (up from $20.7 million in Q4 2024) and $85.9 million for FY 2025 (up from $80.8 million in FY 2024).
G&A expenses rose to $13.0 million for Q4 2025 (from $6.2 million in Q4 2024), mainly due to stock-based compensation related to CEO transition; FY 2025 G&A was $33.8 million (up from $23.8 million in FY 2024).
Net loss was $29.7 million for Q4 2025 (vs. $23.2 million in Q4 2024) and $103.7 million for FY 2025 (vs. $89.0 million in FY 2024).
Outlook and guidance
Additional Phase 1 data from ENABLE trial to be presented mid-2026.
Regulatory alignment with FDA on dose selection and Phase 3 trial design expected in 2026.
ENABLE-2 Phase 3 trial initiation planned for the second half of 2026.
ELVN-001 efficacy in heavily pretreated CML
FDA alignment on ELVN-001 Phase 3 design
How do leadership changes support commercialization?
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Latest events from Enliven Therapeutics
- ELVN-001 advances to phase 3 in CML, targeting post-asciminib patients with strong early data.ELVN
TD Cowen 46th Annual Health Care Conference3 Mar 2026 - Lead assets show strong early data in CML and HER2 cancers; key updates expected in 2024-2025.ELVNGoldman Sachs 45th Annual Global Healthcare Conference1 Feb 2026
- Major clinical updates for CML and HER2 programs expected in 2025, with cash runway to 2026.ELVNJefferies 2024 Global Healthcare Conference31 Jan 2026
- New CML therapies show strong efficacy and safety, targeting broad approval and market growth.ELVNJefferies London Healthcare Conference 202413 Jan 2026
- Shareholders will vote on director elections and auditor ratification, with board-backed nominees.ELVNProxy Filing2 Dec 2025
- Virtual meeting to elect directors and ratify auditor, with board support for both proposals.ELVNProxy Filing2 Dec 2025
- ELVN-001 demonstrates robust efficacy in late-line CML, with a pivotal phase III trial planned.ELVNTD Cowen 45th Annual Healthcare Conference2 Dec 2025
- Promising CML therapy advances toward pivotal trial, with strong efficacy, safety, and cash runway.ELVNJefferies Global Healthcare Conference 202526 Nov 2025
- ELVN-001 demonstrates robust efficacy and safety, with pivotal trials planned for broader CML use.ELVNTD Cowen's 6th Annual Oncology Innovation Summit21 Nov 2025
Next Enliven Therapeutics earnings date
Q1 202611 May, 2026
Enliven Therapeutics
Next Enliven Therapeutics earnings date
Q1 202611 May, 2026
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