Enliven Therapeutics
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Enliven Therapeutics (ELVN) investor relations material

Enliven Therapeutics Q3 2026 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q3 2026 earnings summary5 Nov, 2026

Executive summary

  • FDA alignment on ENABLE-2’s final design supports a planned Phase 3 start before year-end 2026; the trial will evaluate relcobatinib in previously treated CML.

  • Relcobatinib remains the lead clinical program; ELVN-002 development was discontinued and the program is exploring strategic alternatives.

  • Phase 1 ENABLE data were presented at four hematology meetings; preclinical findings on selectivity and resistant-mutation activity appeared in Leukemia.

  • Relcobatinib was adopted as the nonproprietary name for ELVN-001; Kristine Ball joined the Board of Directors.

Financial highlights

  • Q3 2026 operating expenses were $36.0M vs. $25.1M YoY; net loss was $27.7M vs. $20.1M, and loss per share was $0.36 vs. $0.32.

  • 9M 2026 operating expenses were $101.1M vs. $85.4M; net loss was $83.8M vs. $74.0M, and loss per share was $1.21 vs. $1.35.

  • Cash, cash equivalents and marketable securities totaled $884.4M at September 30, 2026, vs. $462.6M at December 31, 2025.

  • No product or other revenue has been generated; meaningful revenue is not expected unless product candidates are approved and commercialized.

Outlook and guidance

  • Cash and marketable securities are expected to fund operations into 2030; a separate filing disclosure says the current operating plan provides at least 12 months of funding from filing.

  • ENABLE-2 is planned to enroll ~450 adults, randomized 1:1 to relcobatinib 80 mg once daily or investigator-selected dasatinib, nilotinib or bosutinib.

  • Primary endpoint is MMR at Week 24, potentially supporting accelerated approval; MMR at Week 96 is the key secondary endpoint that could support full approval.

  • R&D and G&A expenses are expected to increase substantially as clinical development, staffing, manufacturing and potential commercialization needs grow.

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Frequently asked questions

Enliven Therapeutics Inc. is a clinical-stage biopharmaceutical company dedicated to the discovery and development of small molecule kinase inhibitors for cancer treatment. The company aims to address both existing and emerging unmet needs in oncology with a precision approach designed to improve patient survival and overall well-being. Their development pipeline includes advanced candidates such as ELVN-001 and ELVN-002, which are being explored for their potential to offer enhanced selectivity, combinability, and safety in treatment protocols. The company is headquartered in Boulder, Colorado, and its shares are listed on the Nasdaq.