Enliven Therapeutics
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Enliven Therapeutics (ELVN) investor relations material

Enliven Therapeutics Q4 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q4 2025 earnings summary3 Mar, 2026

Executive summary

  • Reported positive initial Phase 1b data for ELVN-001 in chronic myeloid leukemia (CML), showing strong efficacy in heavily pretreated patients.

  • Initiation of Phase 3 ENABLE-2 pivotal trial for ELVN-001 expected in the second half of 2026, with key data readouts and regulatory milestones anticipated throughout 2026.

  • Leadership transition with Rick Fair appointed CEO in December 2025 and Scott Garland joining the Board in January 2026, aligning governance for late-stage development and commercialization.

Financial highlights

  • Cash, cash equivalents, and marketable securities totaled $462.6 million as of December 31, 2025, providing runway into the first half of 2029.

  • R&D expenses were $21.2 million for Q4 2025 (up from $20.7 million in Q4 2024) and $85.9 million for FY 2025 (up from $80.8 million in FY 2024).

  • G&A expenses rose to $13.0 million for Q4 2025 (from $6.2 million in Q4 2024), mainly due to stock-based compensation related to CEO transition; FY 2025 G&A was $33.8 million (up from $23.8 million in FY 2024).

  • Net loss was $29.7 million for Q4 2025 (vs. $23.2 million in Q4 2024) and $103.7 million for FY 2025 (vs. $89.0 million in FY 2024).

Outlook and guidance

  • Additional Phase 1 data from ENABLE trial to be presented mid-2026.

  • Regulatory alignment with FDA on dose selection and Phase 3 trial design expected in 2026.

  • ENABLE-2 Phase 3 trial initiation planned for the second half of 2026.

ELVN-001 efficacy in heavily pretreated CML
FDA alignment on ELVN-001 Phase 3 design
How do leadership changes support commercialization?
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Frequently asked questions

Enliven Therapeutics Inc. is a clinical-stage biopharmaceutical company dedicated to the discovery and development of small molecule kinase inhibitors for cancer treatment. The company aims to address both existing and emerging unmet needs in oncology with a precision approach designed to improve patient survival and overall well-being. Their development pipeline includes advanced candidates such as ELVN-001 and ELVN-002, which are being explored for their potential to offer enhanced selectivity, combinability, and safety in treatment protocols. The company is headquartered in Boulder, Colorado, and its shares are listed on the Nasdaq.

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