EXACT Therapeutics
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EXACT Therapeutics (EXTX) investor relations material

EXACT Therapeutics H2 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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H2 2025 earnings summary9 Apr, 2026

Executive summary

  • Achieved significant progress in advancing PS101 for locally advanced pancreatic cancer, with ENACT Phase 2 trial initiated and first patient treated in June 2025.

  • Positive final results from ACTIVATE Phase 1 trial in liver metastases, showing 4x greater tumor shrinkage with PS101 plus chemotherapy.

  • Strengthened strategic partnership with GE HealthCare and secured additional patents.

  • Maintained a focused strategy on high unmet medical need cancers, especially pancreatic cancer.

Financial highlights

  • Total operating costs for 2025 were NOK 84.9 million, up from NOK 52.9 million in 2024, reflecting increased R&D activity.

  • Comprehensive loss for 2025 was NOK -87.0 million, compared to NOK -52.3 million in 2024.

  • Cash and cash equivalents at year-end 2025 were NOK 24.3 million, down from NOK 100 million at end of 2024.

  • Equity ratio declined to 46% (from 75% in 2024) due to increased expenses and reduced cash position.

  • Government grants recognized totaled NOK 7.8 million in 2025.

Outlook and guidance

  • Focus in 2026 will be on executing the ENACT Phase 2 trial, with interim analysis and patient recruitment completion expected in H2 2026.

  • Strategic partnership with GE HealthCare to continue, aiming for a commercial-ready ultrasound platform.

  • Preclinical programs in blood-brain barrier, immuno-oncology, and gene therapy to progress.

  • Successful warrant exercise in early 2026 raised NOK 59 million, ensuring liquidity for planned activities through 2026 and beyond.

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