Exelixis
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Exelixis (EXEL) investor relations material

Exelixis Q3 2026 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q3 2026 earnings summary29 Oct, 2026

Executive summary

  • Q3 2026 revenue was $658.7M, up 10% YoY; GAAP net income was $218.1M and diluted EPS was $0.85.

  • Cabozantinib growth and zanzalintinib development underpin a multi-franchise oncology strategy, with disciplined investment and shareholder returns.

  • 9M revenue grew 10% YoY to $1.90B; operating cash flow was $839.5M and quarter-end cash and marketable securities totaled $1.40B.

Financial highlights

  • Q3 net product revenue was $604.9M, up 11% YoY; collaboration revenue was $53.8M, down 2% as higher license revenue was offset by lower services revenue.

  • GAAP operating income was $268.4M versus $236.5M; GAAP net income was $218.1M versus $193.6M.

  • Non-GAAP net income was $240.2M and diluted EPS was $0.94, excluding stock-based compensation net of tax.

  • R&D expense was $209.5M, up 5% YoY; SG&A was $154.6M, up 25%, reflecting personnel, clinical trial, marketing, legal and advisory costs.

  • CABOMETYX generated $603.2M in Q3 net product revenue; COMETRIQ revenue was $1.8M.

Outlook and guidance

  • FY 2026 revenue guidance remains $2.500B–$2.550B, including net product revenue of $2.300B–$2.350B.

  • FY 2026 COGS guidance is ~4% of net product revenue; R&D guidance remains $825M–$875M and SG&A $575M–$625M.

  • FY 2026 effective tax-rate guidance fell to 16%–18% from 21%–23%; revenue guidance excludes a potential U.S. zanzalintinib CRC approval and launch.

  • STELLAR-304 top-line results are expected in Q1 2027; positive results could support a second zanzalintinib NDA.

  • Gross margin is expected to remain broadly unchanged for the rest of 2026; higher R&D, clinical, launch-preparation and legal costs may affect spending.

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Frequently asked questions

Exelixis Inc is a biotechnology company focused on developing and commercializing small molecule therapies for cancer treatment. The company engages in drug discovery, clinical development, and partnerships targeting multiple oncology indications. The company is headquartered in Alameda, California, and its shares are listed on the NASDAQ.