ExpreS2ion Biotech
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ExpreS2ion Biotech (EXPRS2) investor relations material

ExpreS2ion Biotech Q4 2025 earnings summary

Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
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Q4 2025 earnings summary19 Feb, 2026

Executive summary

  • Achieved significant clinical and strategic milestones in 2025, including progress in HER2 breast cancer immunotherapy, infectious disease programs, and advanced Phase I clinical trial for ES2B-C001 with positive safety and immunogenicity data.

  • Entered a licensing agreement with Serum Institute of India for malaria vaccine candidates RH5.1 and R78C, securing development and commercialization rights.

  • Progressed Nipah virus vaccine program with VICI-Disease consortium, selecting Northway Biotech as manufacturing partner and preparing clinical supply.

  • Multiple grant-funded programs expanded the pipeline with minimal capital burden, validating the ExpreS2 platform.

  • Strengthened financial position through successful warrant exercise, raising SEK 11.8 million before costs, and maintained focus on cost discipline and capital allocation.

Financial highlights

  • Q4 2025 total income was SEK 3.5 million, up 62% year-on-year; full year income reached SEK 12.2 million, a 56% increase from 2024.

  • Net sales for 2025 were SEK 3.7 million, up 21% year-on-year; grant income rose 78%.

  • Q4 operating costs were SEK 14 million, 37% lower than Q4 2024; personnel costs down 15% year-on-year.

  • Q4 net loss was SEK 8.2 million, a 46% improvement year-on-year; full year net loss SEK 38 million, 6% higher than 2024 due to a one-off gain in 2024.

  • Cash and equivalents at year-end were SEK 47.6 million, down 42% from prior year.

Outlook and guidance

  • Phase I-A data for ES2B-C001 expected mid-2026; Phase I-B data by year-end 2026.

  • Cash position of SEK 48 million as of December 31, 2025, supports advancement to next clinical milestones in 2026.

  • Cost base and cash outflow expected to remain consistent with recent quarters.

  • Ongoing evaluation of capital raising options, with a preference for non-dilutive funding.

  • Focus remains on generating high-quality clinical data and advancing partnered programs.

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Q1 202619 May, 2026
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Q1 202619 May, 2026

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Frequently asked questions

ExpreS2ion Biotech Holding AB (publ), through its subsidiary, ExpreS2 ion Biotechnologies ApS, develops, produces, and delivers therapeutics or diagnostic proteins in Denmark and internationally. The company uses its expression system technology to offer services that include cell line development, screening of cell bank clones developed in the clients' host cell line of interest, analytical services comprising host cell line development, clone screening and base media optimization, process scale-up and GMP manufacturing. It also manufactures and distributes therapeutic proteins based on prokaryotic and eukaryotic expression systems using the GalXC protein expression system to EU/US chemical and health companies.

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