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ExpreS2ion Biotech (EXPRS2) investor relations material
ExpreS2ion Biotech Investing in Life Science 2025 summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.Investing in Life Science 2025 summary25 Sep, 2025
Disease overview and market need
Breast cancer incidence is rising, with 2.3 million new cases and 700,000 deaths annually, projected to reach 3 million cases and 1 million deaths by 2040.
HER2-expressing tumors are present in 80% of cases, with up to 50% of these patients relapsing due to drug resistance.
Incidence in women under 50 has increased by nearly 80% since 1990, making it the leading cancer in this group.
The HER2 breast cancer market is valued at €11 billion annually, with the broader breast cancer market at €27 billion and growing 7% per year.
Addressable market for the new therapy is estimated at over €5 billion per year.
Therapeutic innovation and clinical progress
Developed an immunotherapy using a virus-like particle to induce a strong, targeted immune response against all four extracellular domains of the HER2 receptor.
This polyclonal antibody approach differs from current therapies, which target only one domain.
Preclinical data show robust antibody induction and tumor suppression in resistant breast cancer cell lines and mouse models.
Early phase 1 human data indicate significant HER2-specific antibody increases in the first patient.
Full treatment curve data for the first patient expected in December, with phase 1a safety readout in 2026 and phase 1b efficacy data from 27 patients by end of next year.
Development strategy and partnerships
Initial clinical focus is on metastatic patients who have failed standard therapies, with plans to move earlier in the treatment line.
Phase 2 proof-of-concept study will determine licensing and potential expansion into gastric cancer.
Licensing targeted after phase 2, with potential for early approval if data are strong; phase 3 would be conducted by a partner.
Signed a letter of intent with WuXi Vaccines for manufacturing and commercialization in China; collaboration is ongoing.
Agreement with Technical University of Denmark provides supercomputer access to accelerate early-stage drug development using AI.
Target licensing strategy post-Phase 2?
Key differentiation vs. standard of care?
What is the current cash runway?
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Next ExpreS2ion Biotech earnings date
Q3 202513 Nov, 2025
Next ExpreS2ion Biotech earnings date
Q3 202513 Nov, 2025
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Frequently asked questions
ExpreS2ion Biotech Holding AB (publ), through its subsidiary, ExpreS2 ion Biotechnologies ApS, develops, produces, and delivers therapeutics or diagnostic proteins in Denmark and internationally. The company uses its expression system technology to offer services that include cell line development, screening of cell bank clones developed in the clients' host cell line of interest, analytical services comprising host cell line development, clone screening and base media optimization, process scale-up and GMP manufacturing. It also manufactures and distributes therapeutic proteins based on prokaryotic and eukaryotic expression systems using the GalXC protein expression system to EU/US chemical and health companies.
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