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FibroGen (FGEN) investor relations material
FibroGen H.C. Wainwright 27th Annual Global Investment Conference summary
Complete event summary combining all related documents: earnings call transcript, report, and slide presentation.
Strategic transactions and financial updates
Completed sale of China operations to AstraZeneca for $220M, extending cash runway into 2028 and paying off $75M term loan.
Simplified capital structure and eliminated significant debt overhang.
Net cash payable at closing includes a $10M holdback, expected within nine months.
Oncology pipeline and clinical progress
Advancing an ADC targeting CD46 in prostate cancer, with promising Phase I results: 8.7 months median RPFS, 36% PSA50 response, and 20% ORR.
Phase II monotherapy trial for ADC to start imminently, with interim analysis in H2 2025 and final results 12 months later.
Companion PET imaging agent for patient selection is being integrated into trials.
Ongoing IST at UCSF combining ADC with enzalutamide; top-line results expected Q4 2024.
Roxadustat development and market opportunity
Roxadustat approved in 40+ markets for CKD anemia; now focusing on lower risk myelodysplastic syndrome (MDS).
Phase III trial in high transfusion burden MDS patients planned, with protocol submission in Q4 2024 and trial start in 2026.
Prior Phase III showed 36% transfusion independence in high-burden subgroup vs. 7% for placebo.
Oral administration offers at-home convenience for elderly patients.
Market for lower risk MDS projected to exceed $4B by 2030.
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